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Viruses 2017, 9(11), 327; doi:10.3390/v9110327

Biology of the BKPyV: An Update

EA4294, Unité de Virologie Clinique et Fondamentale, Centre Universitaire de Recherche en Santé, Centre Hospitalier Universitaire et Université de Picardie Jules Verne, 80054 Amiens, France
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Academic Editor: Jens H. Kuhn
Received: 13 October 2017 / Revised: 30 October 2017 / Accepted: 30 October 2017 / Published: 3 November 2017
(This article belongs to the Section Animal Viruses)
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Abstract

The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium. However, reactivation of BKPyV in immunocompromised individuals may cause serious complications. In particular, with the implementation of more potent immunosuppressive drugs in the last decade, BKPyV has become an emerging pathogen in kidney and bone marrow transplant recipients where it often causes associated nephropathy and haemorrhagic cystitis, respectively. Unfortunately, no specific antiviral against BKPyV has been approved yet and the only therapeutic option is a modulation of the immunosuppressive drug regimen to improve immune control though it may increase the risk of rejection. A better understanding of the BKPyV life cycle is thus needed to develop efficient treatment against this virus. In this review, we provide an update on recent advances in understanding the biology of BKPyV. View Full-Text
Keywords: polyomavirus; noncoding control region; archetype; rearranged form; TAg; VP1; Agno; ganglioside; ERAD polyomavirus; noncoding control region; archetype; rearranged form; TAg; VP1; Agno; ganglioside; ERAD
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Helle, F.; Brochot, E.; Handala, L.; Martin, E.; Castelain, S.; Francois, C.; Duverlie, G. Biology of the BKPyV: An Update. Viruses 2017, 9, 327.

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