Protoparvovirus Cell Entry
AbstractThe Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities while being nonpathogenic for humans. The PtPVs invade and replicate within the nucleus making extensive use of the transport, transcription and replication machineries of the host cells. In order to reach the nucleus, PtPVs need to cross over several intracellular barriers and traffic through different cell compartments, which limit their infection efficiency. In this review we summarize molecular interactions, capsid structural transitions and hijacking of cellular processes, by which the PtPVs enter and deliver their single-stranded DNA genome into the host cell nucleus. Understanding mechanisms that govern the complex PtPV entry will be instrumental in developing approaches to boost their anticancer therapeutic potential and improving their safety profile. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Ros, C.; Bayat, N.; Wolfisberg, R.; Almendral, J.M. Protoparvovirus Cell Entry. Viruses 2017, 9, 313.
Ros C, Bayat N, Wolfisberg R, Almendral JM. Protoparvovirus Cell Entry. Viruses. 2017; 9(11):313.Chicago/Turabian Style
Ros, Carlos; Bayat, Nooshin; Wolfisberg, Raphael; Almendral, José M. 2017. "Protoparvovirus Cell Entry." Viruses 9, no. 11: 313.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.