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Viruses 2017, 9(11), 313; doi:10.3390/v9110313

Protoparvovirus Cell Entry

1
Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland
2
Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
3
Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark
*
Authors to whom correspondence should be addressed.
Received: 9 October 2017 / Revised: 21 October 2017 / Accepted: 23 October 2017 / Published: 26 October 2017
(This article belongs to the Special Issue Protoparvoviruses: Friends or Foes?)
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Abstract

The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities while being nonpathogenic for humans. The PtPVs invade and replicate within the nucleus making extensive use of the transport, transcription and replication machineries of the host cells. In order to reach the nucleus, PtPVs need to cross over several intracellular barriers and traffic through different cell compartments, which limit their infection efficiency. In this review we summarize molecular interactions, capsid structural transitions and hijacking of cellular processes, by which the PtPVs enter and deliver their single-stranded DNA genome into the host cell nucleus. Understanding mechanisms that govern the complex PtPV entry will be instrumental in developing approaches to boost their anticancer therapeutic potential and improving their safety profile. View Full-Text
Keywords: parvovirus; Protoparvovirus; icosahedral capsid; receptor binding; capsid rearrangements; endosomal escape; trafficking signals; nuclear import; virus entry parvovirus; Protoparvovirus; icosahedral capsid; receptor binding; capsid rearrangements; endosomal escape; trafficking signals; nuclear import; virus entry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ros, C.; Bayat, N.; Wolfisberg, R.; Almendral, J.M. Protoparvovirus Cell Entry. Viruses 2017, 9, 313.

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