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Viruses 2017, 9(1), 21; doi:10.3390/v9010021

Nuclear Import of Hepatitis B Virus Capsids and Genome

1,2
and
1,2,3,*
1
Laboratoire de Microbiologie Fondamentale et Pathogénicité, University of Bordeaux, UMR 5234, F-33076 Bordeaux, France
2
CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, F-33076 Bordeaux, France
3
Centre Hospitalier Universitaire de Bordeaux, Service de Virologie, F-33076 Bordeaux, France
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 9 December 2016 / Revised: 17 January 2017 / Accepted: 17 January 2017 / Published: 21 January 2017
(This article belongs to the Special Issue Recent Advances in Hepatitis B Virus Research)
View Full-Text   |   Download PDF [2028 KB, uploaded 21 January 2017]   |  

Abstract

Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus. The virus must have thus ways of transporting its DNA genome into this compartment. This review summarizes the data on hepatitis B virus genome transport and correlates the finding to those from other viruses. View Full-Text
Keywords: nuclear transport; genome release; hepatitis B virus; nuclear pore; nucleoporin nuclear transport; genome release; hepatitis B virus; nuclear pore; nucleoporin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gallucci, L.; Kann, M. Nuclear Import of Hepatitis B Virus Capsids and Genome. Viruses 2017, 9, 21.

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