Next Article in Journal
Cross-Species Antiviral Activity of Goose Interferons against Duck Plague Virus Is Related to Its Positive Self-Feedback Regulation and Subsequent Interferon Stimulated Genes Induction
Next Article in Special Issue
A Phylogenetic Survey on the Structure of the HIV-1 Leader RNA Domain That Encodes the Splice Donor Signal
Previous Article in Journal / Special Issue
Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1
Article Menu

Export Article

Open AccessReview
Viruses 2016, 8(7), 194; doi:10.3390/v8070194

RNA Encapsidation and Packaging in the Phleboviruses

1
Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
2
Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT 59812, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Polly Roy and Roland Marquet
Received: 8 June 2016 / Revised: 1 July 2016 / Accepted: 7 July 2016 / Published: 15 July 2016
(This article belongs to the Special Issue RNA Packaging)
View Full-Text   |   Download PDF [673 KB, uploaded 15 July 2016]   |  

Abstract

The Bunyaviridae represents the largest family of segmented RNA viruses, which infect a staggering diversity of plants, animals, and insects. Within the family Bunyaviridae, the Phlebovirus genus includes several important human and animal pathogens, including Rift Valley fever virus (RVFV), severe fever with thrombocytopenia syndrome virus (SFTSV), Uukuniemi virus (UUKV), and the sandfly fever viruses. The phleboviruses have small tripartite RNA genomes that encode a repertoire of 5–7 proteins. These few proteins accomplish the daunting task of recognizing and specifically packaging a tri-segment complement of viral genomic RNA in the midst of an abundance of host components. The critical nucleation events that eventually lead to virion production begin early on in the host cytoplasm as the first strands of nascent viral RNA (vRNA) are synthesized. The interaction between the vRNA and the viral nucleocapsid (N) protein effectively protects and masks the RNA from the host, and also forms the ribonucleoprotein (RNP) architecture that mediates downstream interactions and drives virion formation. Although the mechanism by which all three genomic counterparts are selectively co-packaged is not completely understood, we are beginning to understand the hierarchy of interactions that begins with N-RNA packaging and culminates in RNP packaging into new virus particles. In this review we focus on recent progress that highlights the molecular basis of RNA genome packaging in the phleboviruses. View Full-Text
Keywords: bunyavirus; phlebovirus; RNA packaging bunyavirus; phlebovirus; RNA packaging
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hornak, K.E.; Lanchy, J.-M.; Lodmell, J.S. RNA Encapsidation and Packaging in the Phleboviruses. Viruses 2016, 8, 194.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top