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Viruses 2016, 8(7), 187; doi:10.3390/v8070187

Recombinant Ranaviruses for Studying Evolution of Host–Pathogen Interactions in Ectothermic Vertebrates

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Department of Biological Sciences, California State University San Marcos, 333 S. Twin Oaks Valley Rd., San Marcos, CA 92096, USA
Author to whom correspondence should be addressed.
Academic Editor: Luis Martinez-Sobrido
Received: 5 March 2016 / Revised: 16 June 2016 / Accepted: 23 June 2016 / Published: 6 July 2016
(This article belongs to the Special Issue Replication-Competent Reporter-Expressing Viruses)
View Full-Text   |   Download PDF [724 KB, uploaded 6 July 2016]   |  


Ranaviruses (Iridoviridae) are large DNA viruses that are causing emerging infectious diseases at an alarming rate in both wild and captive cold blood vertebrate species all over the world. Although the general biology of these viruses that presents some similarities with poxvirus is characterized, many aspects of their replication cycles, host cell interactions and evolution still remain largely unclear, especially in vivo. Over several years, strategies to generate site-specific ranavirus recombinant, either expressing fluorescent reporter genes or deficient for particular viral genes, have been developed. We review here these strategies, the main ranavirus recombinants characterized and their usefulness for in vitro and in vivo studies. View Full-Text
Keywords: Amphibians; Xenopus; iridovirus; DNA viruses; reporter virus, recombinant virus Amphibians; Xenopus; iridovirus; DNA viruses; reporter virus, recombinant virus

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Robert, J.; Jancovich, J.K. Recombinant Ranaviruses for Studying Evolution of Host–Pathogen Interactions in Ectothermic Vertebrates. Viruses 2016, 8, 187.

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