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Viruses 2016, 8(7), 180; doi:10.3390/v8070180

Who Regulates Whom? An Overview of RNA Granules and Viral Infections

1
Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile
2
Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago 8330024, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Received: 28 April 2016 / Revised: 10 June 2016 / Accepted: 21 June 2016 / Published: 28 June 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
View Full-Text   |   Download PDF [315 KB, uploaded 4 July 2016]

Abstract

After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs). View Full-Text
Keywords: RNA granules; stress granules; P-bodies; anti-viral host immune response; translation control RNA granules; stress granules; P-bodies; anti-viral host immune response; translation control
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Poblete-Durán, N.; Prades-Pérez, Y.; Vera-Otarola, J.; Soto-Rifo, R.; Valiente-Echeverría, F. Who Regulates Whom? An Overview of RNA Granules and Viral Infections. Viruses 2016, 8, 180.

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