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Viruses 2016, 8(5), 142; doi:10.3390/v8050142

Mechanisms of Cellular Membrane Reorganization to Support Hepatitis C Virus Replication

1
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
3
Medicine Service, Ann Arbor Veterans Administration Health System, Ann Arbor, MI 48105, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Ploss
Received: 3 March 2016 / Revised: 20 April 2016 / Accepted: 15 May 2016 / Published: 20 May 2016
(This article belongs to the Special Issue Host Membranes and the Viral Infection Cycle)
View Full-Text   |   Download PDF [1645 KB, uploaded 20 May 2016]   |  

Abstract

Like all positive-sense RNA viruses, hepatitis C virus (HCV) induces host membrane alterations for its replication termed the membranous web (MW). Assembling replication factors at a membranous structure might facilitate the processes necessary for genome replication and packaging and shield viral components from host innate immune defenses. The biogenesis of the HCV MW is a complex process involving a concerted effort of HCV nonstructural proteins with a growing list of host factors. Although a comprehensive understanding of MW formation is still missing, a number of important viral and host determinants have been identified. This review will summarize the recent studies that have led to our current knowledge of the role of viral and host factors in the biogenesis of the MWs and discuss how HCV uses this specialized membrane structure for its replication. View Full-Text
Keywords: viral replication; double membrane vesicle; RNA virus; phosphatidylinositol 4-phosphate; phosphatidylinositol 4-kinase viral replication; double membrane vesicle; RNA virus; phosphatidylinositol 4-phosphate; phosphatidylinositol 4-kinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, H.; Tai, A.W. Mechanisms of Cellular Membrane Reorganization to Support Hepatitis C Virus Replication. Viruses 2016, 8, 142.

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