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Viruses 2016, 8(5), 130; doi:10.3390/v8050130

Making Bunyaviruses Talk: Interrogation Tactics to Identify Host Factors Required for Infection

1
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jane Tao and Pierre-Yves Lozach
Received: 19 March 2016 / Revised: 3 May 2016 / Accepted: 6 May 2016 / Published: 13 May 2016
(This article belongs to the Special Issue Recent Progress in Bunyavirus Research)
View Full-Text   |   Download PDF [685 KB, uploaded 13 May 2016]   |  

Abstract

The identification of host cellular genes that act as either proviral or antiviral factors has been aided by the development of an increasingly large number of high-throughput screening approaches. Here, we review recent advances in which these new technologies have been used to interrogate host genes for the ability to impact bunyavirus infection, both in terms of technical advances as well as a summary of biological insights gained from these studies. View Full-Text
Keywords: bunyavirus; high-throughput screening; host-pathogen interaction; haploid genetic screening; RNAi screening; yeast two-hybrid; affinity purification mass spectrometry bunyavirus; high-throughput screening; host-pathogen interaction; haploid genetic screening; RNAi screening; yeast two-hybrid; affinity purification mass spectrometry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Riblett, A.M.; Doms, R.W. Making Bunyaviruses Talk: Interrogation Tactics to Identify Host Factors Required for Infection. Viruses 2016, 8, 130.

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