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Viruses 2016, 8(4), 95; doi:10.3390/v8040095

Viral Evasion of Natural Killer Cell Activation

1
Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, No. 74, Zhongshan 2nd Road, Guangzhou 510080, China
2
Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Ploss
Received: 2 February 2016 / Revised: 21 March 2016 / Accepted: 31 March 2016 / Published: 12 April 2016
(This article belongs to the Section Animal Viruses)
View Full-Text   |   Download PDF [799 KB, uploaded 12 April 2016]   |  

Abstract

Natural killer (NK) cells play a key role in antiviral innate defenses because of their abilities to kill infected cells and secrete regulatory cytokines. Additionally, NK cells exhibit adaptive memory-like antigen-specific responses, which represent a novel antiviral NK cell defense mechanism. Viruses have evolved various strategies to evade the recognition and destruction by NK cells through the downregulation of the NK cell activating receptors. Here, we review the recent findings on viral evasion of NK cells via the impairment of NK cell-activating receptors and ligands, which provide new insights on the relationship between NK cells and viral actions during persistent viral infections. View Full-Text
Keywords: natural killer cells; viral evasion; activating receptor; ligands; herpesvirus natural killer cells; viral evasion; activating receptor; ligands; herpesvirus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ma, Y.; Li, X.; Kuang, E. Viral Evasion of Natural Killer Cell Activation. Viruses 2016, 8, 95.

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