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Viruses 2016, 8(3), 81; doi:10.3390/v8030081

Alphaherpesvirus Subversion of Stress-Induced Translational Arrest

Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
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Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Received: 21 January 2016 / Revised: 1 March 2016 / Accepted: 2 March 2016 / Published: 15 March 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
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Abstract

In this article, we provide an overview of translational arrest in eukaryotic cells in response to stress and the tactics used specifically by alphaherpesviruses to overcome translational arrest. One consequence of translational arrest is the formation of cytoplasmic compartments called stress granules (SGs). Many viruses target SGs for disruption and/or modification, including the alphaherpesvirus herpes simplex virus type 2 (HSV-2). Recently, it was discovered that HSV-2 disrupts SG formation early after infection via virion host shutoff protein (vhs), an endoribonuclease that is packaged within the HSV-2 virion. We review this discovery and discuss the insights it has provided into SG biology as well as its potential significance in HSV-2 infection. A model for vhs-mediated disruption of SG formation is presented. View Full-Text
Keywords: alphaherpesvirus; translational arrest; stress granules alphaherpesvirus; translational arrest; stress granules
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Finnen, R.L.; Banfield, B.W. Alphaherpesvirus Subversion of Stress-Induced Translational Arrest. Viruses 2016, 8, 81.

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