In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection
AbstractDevelopments of genome amplification techniques have rapidly expanded the family of human polyomaviruses (PyV). Following infection early in life, PyV persist in their hosts and are generally of no clinical consequence. High-level replication of PyV can occur in patients under immunosuppressive or immunomodulatory therapy and causes severe clinical entities, such as progressive multifocal leukoencephalopathy, polyomavirus-associated nephropathy or Merkel cell carcinoma. The characterization of known and newly-discovered human PyV, their relationship to human health, and the mechanisms underlying pathogenesis remain to be elucidated. Here, we summarize the most widely-used in vitro and in vivo models to study the PyV-host interaction, pathogenesis and anti-viral drug screening. We discuss the strengths and limitations of the different models and the lessons learned. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Barth, H.; Solis, M.; Kack-Kack, W.; Soulier, E.; Velay, A.; Fafi-Kremer, S. In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection. Viruses 2016, 8, 292.
Barth H, Solis M, Kack-Kack W, Soulier E, Velay A, Fafi-Kremer S. In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection. Viruses. 2016; 8(10):292.Chicago/Turabian Style
Barth, Heidi; Solis, Morgane; Kack-Kack, Wallys; Soulier, Eric; Velay, Aurélie; Fafi-Kremer, Samira. 2016. "In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection." Viruses 8, no. 10: 292.