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Viruses 2016, 8(10), 266; doi:10.3390/v8100266

Vesicular Nucleo-Cytoplasmic Transport—Herpesviruses as Pioneers in Cell Biology

Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany
Academic Editors: Eric O. Freed and Thomas Klimkait
Received: 26 August 2016 / Revised: 12 September 2016 / Accepted: 20 September 2016 / Published: 27 September 2016
(This article belongs to the Special Issue Viruses 2016 - At the Forefront of Virus-Host Interactions)
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Abstract

Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm. The molecular basis for this novel vesicular nucleo-cytoplasmic transport is beginning to be elucidated in detail. The heterodimeric viral nuclear egress complex (NEC), conserved within the classical herpesviruses, mediates vesicle formation from the inner nuclear membrane (INM) by polymerization into a hexagonal lattice followed by fusion of the vesicle membrane with the outer nuclear membrane (ONM). Mechanisms of capsid inclusion as well as vesicle-membrane fusion, however, are largely unclear. Interestingly, a similar transport mechanism through the NE has been demonstrated in nuclear export of large ribonucleoprotein complexes during Drosophila neuromuscular junction formation, indicating a widespread presence of a novel concept of cellular nucleo-cytoplasmic transport. View Full-Text
Keywords: herpesvirus; nuclear egress; nuclear egress complex; nucleo-cytoplasmic transport herpesvirus; nuclear egress; nuclear egress complex; nucleo-cytoplasmic transport
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mettenleiter, T.C. Vesicular Nucleo-Cytoplasmic Transport—Herpesviruses as Pioneers in Cell Biology. Viruses 2016, 8, 266.

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