MicroRNA and Pathogenesis of Enterovirus Infection
AbstractThere are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the high genomic mutation rate. To conquer these limits in the development of anti-Enterovirus treatments, a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human genes. The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. In this review, we shed light on recent advances in the understanding of Enterovirus infection-modulated miRNAs. The impacts of altered host miRNAs on cellular processes, including immune escape, apoptosis, signal transduction, shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising strategy for the development of antiviral therapy. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Ho, B.-C.; Yang, P.-C.; Yu, S.-L. MicroRNA and Pathogenesis of Enterovirus Infection. Viruses 2016, 8, 11.
Ho B-C, Yang P-C, Yu S-L. MicroRNA and Pathogenesis of Enterovirus Infection. Viruses. 2016; 8(1):11.Chicago/Turabian Style
Ho, Bing-Ching; Yang, Pan-Chyr; Yu, Sung-Liang. 2016. "MicroRNA and Pathogenesis of Enterovirus Infection." Viruses 8, no. 1: 11.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.