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Viruses 2015, 7(9), 5040-5065; doi:10.3390/v7092860

Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer

Department of Basic Science, Loma Linda University, Loma Linda, CA 92354, USA
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Author to whom correspondence should be addressed.
Academic Editor: Joanna Parish
Received: 17 June 2015 / Revised: 17 August 2015 / Accepted: 27 August 2015 / Published: 17 September 2015
(This article belongs to the Special Issue Tumour Viruses)
View Full-Text   |   Download PDF [715 KB, uploaded 17 September 2015]   |  

Abstract

The rise in human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) has elicited significant interest in the role of high-risk HPV in tumorigenesis. Because patients with HPV-positive HNSCC have better prognoses than do their HPV-negative counterparts, current therapeutic strategies for HPV+ HNSCC are increasingly considered to be overly aggressive, highlighting a need for customized treatment guidelines for this cohort. Additional issues include the unmet need for a reliable screening strategy for HNSCC, as well as the ongoing assessment of the efficacy of prophylactic vaccines for the prevention of HPV infections in the head and neck regions. This review also outlines a number of emerging prospects for therapeutic vaccines, as well as for targeted, molecular-based therapies for HPV-associated head and neck cancers. Overall, the future for developing novel and effective therapeutic agents for HPV-associated head and neck tumors is promising; continued progress is critical in order to meet the challenges posed by the growing epidemic. View Full-Text
Keywords: head and neck squamous cell carcinoma; high risk HPV; HPV-related oropharyngeal squamous cell carcinoma; cancer treatments; target therapy; HNSCC; HR HPV; OPSCC head and neck squamous cell carcinoma; high risk HPV; HPV-related oropharyngeal squamous cell carcinoma; cancer treatments; target therapy; HNSCC; HR HPV; OPSCC
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MDPI and ACS Style

Whang, S.N.; Filippova, M.; Duerksen-Hughes, P. Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer. Viruses 2015, 7, 5040-5065.

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