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Viruses 2015, 7(8), 4624-4639; doi:10.3390/v7082836

Wolbachia Do Not Induce Reactive Oxygen Species-Dependent Immune Pathway Activation in Aedes albopictus

1
Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford OX1 3SY, UK
2
Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Nikolaos Vasilakis
Received: 7 May 2015 / Revised: 3 August 2015 / Accepted: 10 August 2015 / Published: 13 August 2015
(This article belongs to the Special Issue Impact of the Insect Microbiome on Arbovirus Transmission)
View Full-Text   |   Download PDF [855 KB, uploaded 13 August 2015]   |  

Abstract

Aedes albopictus is a major vector of dengue (DENV) and chikungunya (CHIKV) viruses, causing millions of infections annually. It naturally carries, at high frequency, the intracellular inherited bacterial endosymbiont Wolbachia strains wAlbA and wAlbB; transinfection with the higher-density Wolbachia strain wMel from Drosophila melanogaster led to transmission blocking of both arboviruses. The hypothesis that reactive oxygen species (ROS)-induced immune activation plays a role in arbovirus inhibition in this species was examined. In contrast to previous observations in Ae. aegypti, elevation of ROS levels was not observed in either cell lines or mosquito lines carrying the wild-type Wolbachia or higher-density Drosophila Wolbachia strains. There was also no upregulation of genes controlling innate immune pathways or with antioxidant/ROS-producing functions. These data suggest that ROS-mediated immune activation is not an important component of the viral transmission-blocking phenotype in this species. View Full-Text
Keywords: mosquito; Aedes; arbovirus; dengue; chikungunya; ROS mosquito; Aedes; arbovirus; dengue; chikungunya; ROS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Molloy, J.C.; Sinkins, S.P. Wolbachia Do Not Induce Reactive Oxygen Species-Dependent Immune Pathway Activation in Aedes albopictus. Viruses 2015, 7, 4624-4639.

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