Next Article in Journal
Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia
Previous Article in Journal
Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems
Article Menu

Export Article

Open AccessCommentary
Viruses 2015, 7(7), 3857-3862; doi:10.3390/v7072801

A Viral Pilot for HCMV Navigation?

Max von Pettenkofer-Institute for Virology, Ludwig-Maximilians-University Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany
Academic Editor: Rachel Van Duyne
Received: 15 May 2015 / Revised: 7 July 2015 / Accepted: 10 July 2015 / Published: 15 July 2015
View Full-Text   |   Download PDF [490 KB, uploaded 15 July 2015]   |  

Abstract

gH/gL virion envelope glycoprotein complexes of herpesviruses serve as entry complexes and mediate viral cell tropism. By binding additional viral proteins, gH/gL forms multimeric complexes which bind to specific host cell receptors. Both Epstein–Barr virus (EBV) and human cytomegalovirus (HCMV) express alternative multimeric gH/gL complexes. Relative amounts of these alternative complexes in the viral envelope determine which host cells are preferentially infected. Host cells of EBV can modulate the gH/gL complex complement of progeny viruses by cell type-dependent degradation of one of the associating proteins. Host cells of HCMV modulate the tropism of their virus progenies by releasing or not releasing virus populations with a specific gH/gL complex complement out of a heterogeneous pool of virions. The group of Jeremy Kamil has recently shown that the HCMV ER-resident protein UL148 controls integration of one of the HCMV gH/gL complexes into virions and thus creates a pool of virions which can be routed by different host cells. This first mechanistic insight into regulation of the gH/gL complex complement of HCMV progenies presents UL148 as a pilot candidate for HCMV navigation in its infected host. View Full-Text
Keywords: human cytomegalovirus; gH/gL glycoprotein complexes; virus navigation; UL148 human cytomegalovirus; gH/gL glycoprotein complexes; virus navigation; UL148
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Adler, B. A Viral Pilot for HCMV Navigation? Viruses 2015, 7, 3857-3862.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top