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Viruses 2015, 7(7), 3835-3856; doi:10.3390/v7072800

Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems

1
Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy
2
Veneto Institute of Oncology IOV IRCCS, via Gattamelata 64, Padova 35128, Italy
3
Microbiology and Virology Unit, Padova University Hospital, via Giustiniani 2, Padova 35128, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 24 May 2015 / Revised: 3 July 2015 / Accepted: 7 July 2015 / Published: 13 July 2015
(This article belongs to the Special Issue Gene Technology and Resistance to Viruses - Reviews)
View Full-Text   |   Download PDF [324 KB, uploaded 13 July 2015]   |  

Abstract

The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate patient-specific models for the investigation of host–pathogen interactions and to develop new antimicrobial and antiviral therapies. Applications of iPSC technology to the study of viral infections in humans have included in vitro modeling of viral infections of neural, liver, and cardiac cells; modeling of human genetic susceptibility to severe viral infectious diseases, such as encephalitis and severe influenza; genetic engineering and genome editing of patient-specific iPSC-derived cells to confer antiviral resistance. View Full-Text
Keywords: human induced pluripotent stem cells; viral infection; patient-specific disease model; genome editing; genetic susceptibility; antiviral resistance; CRISPR/Cas9; personalized therapy; hepatitis C virus; human immunodeficiency virus human induced pluripotent stem cells; viral infection; patient-specific disease model; genome editing; genetic susceptibility; antiviral resistance; CRISPR/Cas9; personalized therapy; hepatitis C virus; human immunodeficiency virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Trevisan, M.; Sinigaglia, A.; Desole, G.; Berto, A.; Pacenti, M.; Palù, G.; Barzon, L. Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems. Viruses 2015, 7, 3835-3856.

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