Next Article in Journal
Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases
Next Article in Special Issue
The Impact of Wolbachia on Virus Infection in Mosquitoes
Previous Article in Journal
Adenovirus 36 and Obesity: An Overview
Previous Article in Special Issue
The Role of RNA Interference (RNAi) in Arbovirus-Vector Interactions
Article Menu

Export Article

Open AccessReview
Viruses 2015, 7(7), 3741-3767; doi:10.3390/v7072795

Tissue Barriers to Arbovirus Infection in Mosquitoes

1
Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
2
Division of Biology, Kansas State University, Manhattan, KS 66506, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 2 May 2015 / Revised: 1 July 2015 / Accepted: 3 July 2015 / Published: 8 July 2015
(This article belongs to the Special Issue Interactions between Arboviruses and Arthropod Vectors)
View Full-Text   |   Download PDF [830 KB, uploaded 8 July 2015]   |  

Abstract

Arthropod-borne viruses (arboviruses) circulate in nature between arthropod vectors and vertebrate hosts. Arboviruses often cause devastating diseases in vertebrate hosts, but they typically do not cause significant pathology in their arthropod vectors. Following oral acquisition of a viremic bloodmeal from a vertebrate host, the arbovirus disease cycle requires replication in the cellular environment of the arthropod vector. Once the vector has become systemically and persistently infected, the vector is able to transmit the virus to an uninfected vertebrate host. In order to systemically infect the vector, the virus must cope with innate immune responses and overcome several tissue barriers associated with the midgut and the salivary glands. In this review we describe, in detail, the typical arbovirus infection route in competent mosquito vectors. Based on what is known from the literature, we explain the nature of the tissue barriers that arboviruses are confronted with in a mosquito vector and how arboviruses might surmount these barriers. We also point out controversial findings to highlight particular areas that are not well understood and require further research efforts. View Full-Text
Keywords: arbovirus; mosquito; midgut; dissemination; salivary gland; tissue barrier; basal lamina; midgut infection barrier; midgut escape barrier arbovirus; mosquito; midgut; dissemination; salivary gland; tissue barrier; basal lamina; midgut infection barrier; midgut escape barrier
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Franz, A.W.E.; Kantor, A.M.; Passarelli, A.L.; Clem, R.J. Tissue Barriers to Arbovirus Infection in Mosquitoes. Viruses 2015, 7, 3741-3767.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top