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Viruses 2015, 7(7), 3647-3674; doi:10.3390/v7072792

Early Events in Chikungunya Virus Infection—From Virus CellBinding to Membrane Fusion

Department of Medical Microbiology, University of Groningen and University Medical Center Groningen, 9700 RB Groningen, The Netherlands
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Academic Editors: Yorgo Modis and Stephen Graham
Received: 4 May 2015 / Revised: 24 June 2015 / Accepted: 29 June 2015 / Published: 7 July 2015
(This article belongs to the Special Issue Viruses and Exosomes)
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Abstract

Chikungunya virus (CHIKV) is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical and subtropical regions of the world. CHIKV infection often leads to an acute self-limited febrile illness with debilitating myalgia and arthralgia. A potential long-term complication of CHIKV infection is severe joint pain, which can last for months to years. There are no vaccines or specific therapeutics available to prevent or treat infection. This review describes the critical steps in CHIKV cell entry. We summarize the latest studies on the virus-cell tropism, virus-receptor binding, internalization, membrane fusion and review the molecules and compounds that have been described to interfere with virus cell entry. The aim of the review is to give the reader a state-of-the-art overview on CHIKV cell entry and to provide an outlook on potential new avenues in CHIKV research. View Full-Text
Keywords: Chikungunya virus; alphavirus; cell tropism; receptor; entry; endocytosis; clathrin; fusion; neutralizing antibodies; entry inhibitors Chikungunya virus; alphavirus; cell tropism; receptor; entry; endocytosis; clathrin; fusion; neutralizing antibodies; entry inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

van Duijl-Richter, M.K.S.; Hoornweg, T.E.; Rodenhuis-Zybert, I.A.; Smit, J.M. Early Events in Chikungunya Virus Infection—From Virus CellBinding to Membrane Fusion. Viruses 2015, 7, 3647-3674.

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