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Viruses 2015, 7(7), 3483-3499; doi:10.3390/v7072782

Pan-Genome Analysis of Brazilian Lineage A Amoebal Mimiviruses

1
Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 Minas Gerais, Brazil
2
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Univ., 13385 Marseille, France
3
Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589 Jeddah, Saudi Arabia
4
Centro de Ciências Biológicas, Departamento de Microbiologia e Parasitologia, Laboratório de Virologia Aplicada, Universidade Federal de Santa Catarina, Florianópolis, 88040-900 Santa Catarina, Brazil
5
Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 13385 Marseille, France
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Hohn
Received: 3 April 2015 / Revised: 15 June 2015 / Accepted: 18 June 2015 / Published: 26 June 2015
(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
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Abstract

Since the recent discovery of Samba virus, the first representative of the family Mimiviridae from Brazil, prospecting for mimiviruses has been conducted in different environmental conditions in Brazil. Recently, we isolated using Acanthamoeba sp. three new mimiviruses, all of lineage A of amoebal mimiviruses: Kroon virus from urban lake water; Amazonia virus from the Brazilian Amazon river; and Oyster virus from farmed oysters. The aims of this work were to sequence and analyze the genome of these new Brazilian mimiviruses (mimi-BR) and update the analysis of the Samba virus genome. The genomes of Samba virus, Amazonia virus and Oyster virus were 97%–99% similar, whereas Kroon virus had a low similarity (90%–91%) with other mimi-BR. A total of 3877 proteins encoded by mimi-BR were grouped into 974 orthologous clusters. In addition, we identified three new ORFans in the Kroon virus genome. Additional work is needed to expand our knowledge of the diversity of mimiviruses from Brazil, including if and why among amoebal mimiviruses those of lineage A predominate in the Brazilian environment. View Full-Text
Keywords: Mimiviridae; Samba virus; pan-genome; mimivirus; Megavirales; Amazonia virus; oyster virus; Kroon virus; genomics Mimiviridae; Samba virus; pan-genome; mimivirus; Megavirales; Amazonia virus; oyster virus; Kroon virus; genomics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Assis, F.L.; Bajrai, L.; Abrahao, J.S.; Kroon, E.G.; Dornas, F.P.; Andrade, K.R.; Boratto, P.V.M.; Pilotto, M.R.; Robert, C.; Benamar, S.; Scola, B.L.; Colson, P. Pan-Genome Analysis of Brazilian Lineage A Amoebal Mimiviruses. Viruses 2015, 7, 3483-3499.

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