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Viruses 2015, 7(7), 3392-3419; doi:10.3390/v7072778

Plant Translation Factors and Virus Resistance

Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, 4200 Highway 97, Summerland, BC V0H 1Z0, Canada
Academic Editor: Thomas Hohn
Received: 12 May 2015 / Revised: 18 June 2015 / Accepted: 19 June 2015 / Published: 24 June 2015
(This article belongs to the Special Issue Gene Technology and Resistance to Viruses - Reviews)
View Full-Text   |   Download PDF [516 KB, uploaded 24 June 2015]   |  

Abstract

Plant viruses recruit cellular translation factors not only to translate their viral RNAs but also to regulate their replication and potentiate their local and systemic movement. Because of the virus dependence on cellular translation factors, it is perhaps not surprising that many natural plant recessive resistance genes have been mapped to mutations of translation initiation factors eIF4E and eIF4G or their isoforms, eIFiso4E and eIFiso4G. The partial functional redundancy of these isoforms allows specific mutation or knock-down of one isoform to provide virus resistance without hindering the general health of the plant. New possible targets for antiviral strategies have also been identified following the characterization of other plant translation factors (eIF4A-like helicases, eIF3, eEF1A and eEF1B) that specifically interact with viral RNAs and proteins and regulate various aspects of the infection cycle. Emerging evidence that translation repression operates as an alternative antiviral RNA silencing mechanism is also discussed. Understanding the mechanisms that control the development of natural viral resistance and the emergence of virulent isolates in response to these plant defense responses will provide the basis for the selection of new sources of resistance and for the intelligent design of engineered resistance that is broad-spectrum and durable. View Full-Text
Keywords: eukaryotic translation initiation factors; recessive resistance; translation repression; plant-virus interactions eukaryotic translation initiation factors; recessive resistance; translation repression; plant-virus interactions
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sanfaçon, H. Plant Translation Factors and Virus Resistance. Viruses 2015, 7, 3392-3419.

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