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Viruses 2015, 7(5), 2185-2209; doi:10.3390/v7052185

Genetic Characterization of the Tick-Borne Orbiviruses

1
Vector-borne Viral Diseases Programme, The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
2
Department of Animal Biotechnology, LLR University of Veterinary and Animal Sciences, Hisar 125 004, Haryana, India
3
Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
4
Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555–0609, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 2 February 2015 / Revised: 18 March 2015 / Accepted: 21 April 2015 / Published: 28 April 2015
(This article belongs to the Section Animal Viruses)
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Abstract

The International Committee for Taxonomy of Viruses (ICTV) recognizes four species of tick-borne orbiviruses (TBOs): Chenuda virus, Chobar Gorge virus, Wad Medani virus and Great Island virus (genus Orbivirus, family Reoviridae). Nucleotide (nt) and amino acid (aa) sequence comparisons provide a basis for orbivirus detection and classification, however full genome sequence data were only available for the Great Island virus species. We report representative genome-sequences for the three other TBO species (virus isolates: Chenuda virus (CNUV); Chobar Gorge virus (CGV) and Wad Medani virus (WMV)). Phylogenetic comparisons show that TBOs cluster separately from insect-borne orbiviruses (IBOs). CNUV, CGV, WMV and GIV share low level aa/nt identities with other orbiviruses, in ‘conserved’ Pol, T2 and T13 proteins/genes, identifying them as four distinct virus-species. The TBO genome segment encoding cell attachment, outer capsid protein 1 (OC1), is approximately half the size of the equivalent segment from insect-borne orbiviruses, helping to explain why tick-borne orbiviruses have a ~1 kb smaller genome. View Full-Text
Keywords: Chenuda virus; Chobar Gorge virus; Wad Medani virus; Great Island virus; Kemorovo virus; Orbivirus; Reoviridae; full genome; dsRNA virus; sequencing Chenuda virus; Chobar Gorge virus; Wad Medani virus; Great Island virus; Kemorovo virus; Orbivirus; Reoviridae; full genome; dsRNA virus; sequencing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Belaganahalli, M.N.; Maan, S.; Maan, N.S.; Brownlie, J.; Tesh, R.; Attoui, H.; Mertens, P.P.C. Genetic Characterization of the Tick-Borne Orbiviruses. Viruses 2015, 7, 2185-2209.

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