The A, B, Cs of Herpesvirus Capsids
AbstractAssembly of herpesvirus nucleocapsids shares significant similarities with the assembly of tailed dsDNA bacteriophages; however, important differences exist. A unique feature of herpesviruses is the presence of different mature capsid forms in the host cell nucleus during infection. These capsid forms, referred to as A-, B-, and C-capsids, represent empty capsids, scaffold containing capsids and viral DNA containing capsids, respectively. The C-capsids are the closest in form to those encapsidated into mature virions and are considered precursors to infectious virus. The evidence supporting A- and B-capsids as either abortive forms or assembly intermediates has been lacking. Interaction of specific capsid forms with viral tegument proteins has been proposed to be a mechanism for quality control at the point of nuclear egress of mature particles. Here, we will review the available literature on these capsid forms and present data to debate whether A- and B-capsids play an important or an extraneous role in the herpesvirus life cycle. View Full-Text
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Tandon, R.; Mocarski, E.S.; Conway, J.F. The A, B, Cs of Herpesvirus Capsids. Viruses 2015, 7, 899-914.
Tandon R, Mocarski ES, Conway JF. The A, B, Cs of Herpesvirus Capsids. Viruses. 2015; 7(3):899-914.Chicago/Turabian Style
Tandon, Ritesh; Mocarski, Edward S.; Conway, James F. 2015. "The A, B, Cs of Herpesvirus Capsids." Viruses 7, no. 3: 899-914.