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Viruses 2015, 7(3), 873-886; doi:10.3390/v7030873

Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus

1
Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo A.C (CIAD) Carretera a la Victoria Km 0.6, C.P. 83304 Hermosillo, Sonora, Mexico
2
Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
3
Departament de Sanitat i d'Anatomia Animals, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 5 November 2014 / Revised: 8 February 2015 / Accepted: 15 February 2015 / Published: 24 February 2015
(This article belongs to the Section Animal Viruses)
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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is currently one of the most important viruses affecting the swine industry worldwide. Despite the large number of papers published each year, the participation of non-structural proteins (nsps) in the immune response is not completely clear. nsps have been involved in the host innate immune response, specifically, nsp1α/β, nsp2, nsp4 and nsp11 have been associated with the immunomodulation capability of the virus. To date, only participation by nsp1, nsp2, nsp4 and nsp7 in the humoral immune response has been reported, with the role of other nsps being overlooked. Furthermore, nsp1, nsp2, nsp5, nsp7 nsp9, nsp10, nsp11 have been implicated in the induction of IFN-γ and probably in the development of the cell-mediated immune response. This review discusses recent reports involving the participation of nsps in the modulation of the innate immune response and their role in the induction of both the humoral and cellular immune responses. View Full-Text
Keywords: PRRSV; non-structural proteins; immune response PRRSV; non-structural proteins; immune response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rascón-Castelo, E.; Burgara-Estrella, A.; Mateu, E.; Hernández, J. Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus. Viruses 2015, 7, 873-886.

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