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Viruses 2015, 7(12), 6730-6738; doi:10.3390/v7122970

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

1
Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
2
German Center for Infection Research, Heidelberg University, 69120 Heidelberg, Germany
Academic Editor: Rachel Van Duyne
Received: 27 October 2015 / Revised: 15 December 2015 / Accepted: 16 December 2015 / Published: 19 December 2015
(This article belongs to the Section Editorial)
View Full-Text   |   Download PDF [492 KB, uploaded 19 December 2015]   |  

Abstract

The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1 accessory proteins Vif, Vpr and Vpu, Nef was, until recently, not known to antagonize the antiviral activity of a host cell restriction factor. Two recent reports now describe the host cell proteins serine incorporator 3 and 5 (SERINC3 and SERINC5) as potent inhibitors of HIV-1 particle infectivity and demonstrate that Nef counteracts these effects. These findings establish SERINC3/5 as restrictions to HIV replication in human cells and define a novel activity for the HIV pathogenesis factor Nef. View Full-Text
Keywords: HIV-1; restriction factors; Nef protein; virion infectivity; SERINC3; SERINC5 HIV-1; restriction factors; Nef protein; virion infectivity; SERINC3; SERINC5
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MDPI and ACS Style

Fackler, O.T. Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor. Viruses 2015, 7, 6730-6738.

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