Next Article in Journal
Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications
Next Article in Special Issue
Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus
Previous Article in Journal
Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?
Article Menu

Export Article

Open AccessArticle
Viruses 2015, 7(11), 5987-6008; doi:10.3390/v7112918

Genetic and Phylogenetic Characterization of Tataguine and Witwatersrand Viruses and Other Orthobunyaviruses of the Anopheles A, Capim, Guamá, Koongol, Mapputta, Tete, and Turlock Serogroups

1
D.I. Ivanovsky Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098, Moscow, Russia
2
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jane Tao and Pierre-Yves Lozach
Received: 2 September 2015 / Revised: 22 October 2015 / Accepted: 7 November 2015 / Published: 23 November 2015
(This article belongs to the Special Issue Recent Progress in Bunyavirus Research)
View Full-Text   |   Download PDF [11731 KB, uploaded 23 November 2015]   |  

Abstract

The family Bunyaviridae has more than 530 members that are distributed among five genera or remain to be classified. The genus Orthobunyavirus is the most diverse bunyaviral genus with more than 220 viruses that have been assigned to more than 18 serogroups based on serological cross-reactions and limited molecular-biological characterization. Sequence information for all three orthobunyaviral genome segments is only available for viruses belonging to the Bunyamwera, Bwamba/Pongola, California encephalitis, Gamboa, Group C, Mapputta, Nyando, and Simbu serogroups. Here we present coding-complete sequences for all three genome segments of 15 orthobunyaviruses belonging to the Anopheles A, Capim, Guamá, Kongool, Tete, and Turlock serogroups, and of two unclassified bunyaviruses previously not known to be orthobunyaviruses (Tataguine and Witwatersrand viruses). Using those sequence data, we established the most comprehensive phylogeny of the Orthobunyavirus genus to date, now covering 15 serogroups. Our results emphasize the high genetic diversity of orthobunyaviruses and reveal that the presence of the small nonstructural protein (NSs)-encoding open reading frame is not as common in orthobunyavirus genomes as previously thought. View Full-Text
Keywords: Anopheles A virus; bunyavirus; Capim virus; Guamá virus; Koongol virus; orthobunyavirus; Tataguine virus; Tete virus; Turlock virus; Witwatersrand virus Anopheles A virus; bunyavirus; Capim virus; Guamá virus; Koongol virus; orthobunyavirus; Tataguine virus; Tete virus; Turlock virus; Witwatersrand virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shchetinin, A.M.; Lvov, D.K.; Deriabin, P.G.; Botikov, A.G.; Gitelman, A.K.; Kuhn, J.H.; Alkhovsky, S.V. Genetic and Phylogenetic Characterization of Tataguine and Witwatersrand Viruses and Other Orthobunyaviruses of the Anopheles A, Capim, Guamá, Koongol, Mapputta, Tete, and Turlock Serogroups. Viruses 2015, 7, 5987-6008.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top