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Viruses 2015, 7(11), 5902-5907; doi:10.3390/v7112917

Chikungunya Virus Replication in Salivary Glands of the Mosquito Aedes albopictus

1
Arboviruses and Insect Vectors Unit, Department of Virology, Institute Pasteur, 25-28 rue du Docteur Roux, 75724 Paris cedex 15, France
2
Ultrapole, Center for Innovation and Technology Research, Institute Pasteur, 25-28 rue du Docteur Roux, 75724 Paris cedex 15, France
Current address: Laboratory of Medical Entomology, Environment and Health, Institute Pasteur of Guadeloupe, Les Abymes, 97183 Guadeloupe, France
*
Author to whom correspondence should be addressed.
Academic Editor: Karyn Johnson
Received: 2 October 2015 / Revised: 10 November 2015 / Accepted: 11 November 2015 / Published: 17 November 2015
(This article belongs to the Section Insect Viruses)
View Full-Text   |   Download PDF [3548 KB, uploaded 17 November 2015]   |  

Abstract

Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standardized protocol to visualize viral particles in the mosquito salivary glands using transmission electron microscopy. Here we provide direct evidence for CHIKV replication and storage in Ae. albopictus salivary glands. View Full-Text
Keywords: Chikungunya virus; Aedes albopictus; salivary glands; budding; replication; transmission electron microscopy Chikungunya virus; Aedes albopictus; salivary glands; budding; replication; transmission electron microscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vega-Rúa, A.; Schmitt, C.; Bonne, I.; Krijnse Locker, J.; Failloux, A.-B. Chikungunya Virus Replication in Salivary Glands of the Mosquito Aedes albopictus. Viruses 2015, 7, 5902-5907.

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