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Viruses 2015, 7(11), 5792-5800; doi:10.3390/v7112906

Genomic Mining Reveals Deep Evolutionary Relationships between Bornaviruses and Bats

Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857, Singapore
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Academic Editors: Johnson Mak, Peter Walker and Marcus Thomas Gilbert
Received: 21 July 2015 / Revised: 5 October 2015 / Accepted: 3 November 2015 / Published: 10 November 2015
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Abstract

Bats globally harbor viruses in order Mononegavirales, such as lyssaviruses and henipaviruses; however, little is known about their relationships with bornaviruses. Previous studies showed that viral fossils of bornaviral origin are embedded in the genomes of several mammalian species such as primates, indicative of an ancient origin of exogenous bornaviruses. In this study, we mined the available 10 bat genomes and recreated a clear evolutionary relationship of endogenous bornaviral elements and bats. Comparative genomics showed that endogenization of bornaviral elements frequently occurred in vesper bats, harboring EBLLs (endogenous bornavirus-like L elements) in their genomes. Molecular dating uncovered a continuous bornavirus-bat interaction spanning 70 million years. We conclude that better understanding of modern exogenous bornaviral circulation in bat populations is warranted. View Full-Text
Keywords: genomic mining; endogenous bornaviruses; bats; virus-host interaction genomic mining; endogenous bornaviruses; bats; virus-host interaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cui, J.; Wang, L.-F. Genomic Mining Reveals Deep Evolutionary Relationships between Bornaviruses and Bats. Viruses 2015, 7, 5792-5800.

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