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Viruses 2015, 7(11), 5705-5717; doi:10.3390/v7112903

The Impact of Wolbachia on Virus Infection in Mosquitoes

School of Biological Sciences, The University of Queensland, Brisbane 4072, Australia
Academic Editor: Rollie Clem
Received: 30 July 2015 / Revised: 7 October 2015 / Accepted: 22 October 2015 / Published: 4 November 2015
(This article belongs to the Special Issue Interactions between Arboviruses and Arthropod Vectors)
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Abstract

Mosquito-borne viruses such as dengue, West Nile and chikungunya viruses cause significant morbidity and mortality in human populations. Since current methods are not sufficient to control disease occurrence, novel methods to control transmission of arboviruses would be beneficial. Recent studies have shown that virus infection and transmission in insects can be impeded by co-infection with the bacterium Wolbachia pipientis. Wolbachia is a maternally inherited endosymbiont that is commonly found in insects, including a number of mosquito vector species. In Drosophila, Wolbachia mediates antiviral protection against a broad range of RNA viruses. This discovery pointed to a potential strategy to interfere with mosquito transmission of arboviruses by artificially infecting mosquitoes with Wolbachia. This review outlines research on the prevalence of Wolbachia in mosquito vector species and the impact of antiviral effects in both naturally and artificially Wolbachia-infected mosquitoes. View Full-Text
Keywords: Wolbachia; Drosophila; mosquito; arbovirus; insect virus; symbiosis; antiviral protection; antiviral effects Wolbachia; Drosophila; mosquito; arbovirus; insect virus; symbiosis; antiviral protection; antiviral effects
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Johnson, K.N. The Impact of Wolbachia on Virus Infection in Mosquitoes. Viruses 2015, 7, 5705-5717.

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