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Viruses 2014, 6(2), 832-855; doi:10.3390/v6020832
Review

The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications

1
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 and 1,*
Received: 18 December 2013; in revised form: 10 February 2014 / Accepted: 11 February 2014 / Published: 17 February 2014
(This article belongs to the Special Issue Adenoviral Vectors)
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Abstract: A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials. The pre-existing immunity, the marked liver tropism and the high toxicity of first generation Ad (FG-Ad) vectors have been the main challenges for the development of new approaches. Significant effort toward the development of genetically and chemically modified adenoviral vectors has enabled researchers to create more sophisticated vectors for gene therapy, with an improved safety profile and a higher transduction ability of different tissues. In this review, we will describe the latest findings in the high-speed, evolving field of genetic and chemical modifications of adenoviral vectors, a field in which different disciplines, such as biomaterial research, virology and immunology, co-operate synergistically to create better gene therapy tools for modern challenges.
Keywords: gene therapy; adenoviral vectors; genetic modification; chimeric fibers; surface modification; pseudotyping; polymers; immunogenicity; re-targeting gene therapy; adenoviral vectors; genetic modification; chimeric fibers; surface modification; pseudotyping; polymers; immunogenicity; re-targeting
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Capasso, C.; Garofalo, M.; Hirvinen, M.; Cerullo, V. The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications. Viruses 2014, 6, 832-855.

AMA Style

Capasso C, Garofalo M, Hirvinen M, Cerullo V. The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications. Viruses. 2014; 6(2):832-855.

Chicago/Turabian Style

Capasso, Cristian; Garofalo, Mariangela; Hirvinen, Mari; Cerullo, Vincenzo. 2014. "The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications." Viruses 6, no. 2: 832-855.



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