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Viruses 2014, 6(10), 3827-3836; doi:10.3390/v6103827

Spread of Oropouche Virus into the Central Nervous System in Mouse

1
Department of Cell Biology, University of Sao Paulo, School of Medicine at Ribeirao Preto, Ribeirao Preto, 14049-900, Brazil
2
Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
3
Department of Neurology and Behavioral Sciences, University of Sao Paulo, School of Medicine at Ribeirao Preto, Ribeirao Preto, 14049-900, Brazil
*
Author to whom correspondence should be addressed.
Received: 6 August 2014 / Revised: 23 September 2014 / Accepted: 24 September 2014 / Published: 10 October 2014
(This article belongs to the Section Animal Viruses)
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Abstract

Oropouche virus (OROV) is an important cause of arboviral illness in Brazil and other Latin American countries, with most cases clinically manifested as acute febrile illness referred to as Oropouche fever, including myalgia, headache, arthralgia and malaise. However, OROV can also affect the central nervous system (CNS) with clinical neurological implications. Little is known regarding OROV pathogenesis, especially how OROV gains access to the CNS. In the present study, neonatal BALB/c mice were inoculated with OROV by the subcutaneous route and the progression of OROV spread into the CNS was evaluated. Immunohistochemistry revealed that OROV infection advances from posterior parts of the brain, including the periaqueductal gray, toward the forebrain. In the early phases of the infection OROV gains access to neural routes, reaching the spinal cord and ascending to the brain through brainstem regions, with little inflammation. Later, as infection progresses, OROV crosses the blood-brain barrier, resulting in more intense spread into the brain parenchyma, with more severe manifestations of encephalitis. View Full-Text
Keywords: Oropouche virus; neuropathogenesis; brainstem Oropouche virus; neuropathogenesis; brainstem
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Santos, R.I.; Bueno-Júnior, L.S.; Ruggiero, R.N.; Almeida, M.F.; Silva, M.L.; Paula, F.E.; Correa, V.M.A.; Arruda, E. Spread of Oropouche Virus into the Central Nervous System in Mouse. Viruses 2014, 6, 3827-3836.

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