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Viruses 2014, 6(10), 3787-3808; doi:10.3390/v6103787

From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation

1,2,†
,
1,2,†
,
1,2,3
and
1,2,4,*
1
Experimental Therapeutics Laboratory, Hanson Institute and Sansom Institute, Adelaide, 5000, SA, Australia
2
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 5000, SA, Australia
3
Sementis, Ltd., Melbourne, 3000, Vic, Australia
4
School of Medicine, University of Adelaide, Adelaide, 5005, SA, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 September 2014 / Revised: 29 September 2014 / Accepted: 2 October 2014 / Published: 7 October 2014
(This article belongs to the Special Issue Virus Maturation)
View Full-Text   |   Download PDF [560 KB, uploaded 12 May 2015]   |  

Abstract

Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outstanding questions, in particular, the origin and biogenesis of the virion membrane, the transformation from immature virion (IV) to mature virus (MV), and the role of several novel genes, which were previously uncharacterized, but have now been shown to be essential for VACV virion formation. This new knowledge will undoubtedly contribute to the rational design of safe, immunogenic vaccine candidates, or effective antivirals in the future. This review endeavors to provide an update on our current knowledge of the VACV maturation processes with a specific focus on the initiation of VACV replication through to the formation of mature virions. View Full-Text
Keywords: vaccinia virus; virus assembly; membrane biogenesis; virion formation vaccinia virus; virus assembly; membrane biogenesis; virion formation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, L.; Cooper, T.; Howley, P.M.; Hayball, J.D. From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation. Viruses 2014, 6, 3787-3808.

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