Viruses 2014, 6(1), 264-283; doi:10.3390/v6010264
Review

Understanding the Process of Envelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses

Laboratorio de Virología, CONICET-Universidad de Belgrano (UB), Buenos Aires C1426BMJ, Argentina
* Author to whom correspondence should be addressed.
Received: 4 November 2013; in revised form: 1 January 2014 / Accepted: 6 January 2014 / Published: 16 January 2014
(This article belongs to the Special Issue Viral Glycoprotein Incorporation)
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Abstract: The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis. Therefore, Env incorporation into the virions formed by assembly of the viral Gag polyprotein at the plasma membrane of the infected cells is a key step in the replication cycle of lentiviruses. Besides being useful models of human immunodeficiency virus (HIV) infections in humans and valuable tools for developing AIDS therapies and vaccines, simian and feline immunodeficiency viruses (SIV and FIV, respectively) are relevant animal retroviruses; the study of which provides important information on how lentiviral replication strategies have evolved. In this review, we discuss the molecular mechanisms underlying the incorporation of the SIV and FIV Env glycoproteins into viral particles.
Keywords: Simian immunodeficiency virus; feline immunodeficiency virus; Gag polyprotein; matrix protein; envelope glycoprotein; envelope incorporation

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MDPI and ACS Style

Affranchino, J.L.; González, S.A. Understanding the Process of Envelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses. Viruses 2014, 6, 264-283.

AMA Style

Affranchino JL, González SA. Understanding the Process of Envelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses. Viruses. 2014; 6(1):264-283.

Chicago/Turabian Style

Affranchino, José L.; González, Silvia A. 2014. "Understanding the Process of Envelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses." Viruses 6, no. 1: 264-283.

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