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Viruses 2012, 4(9), 1731-1752; doi:10.3390/v4091731
Review

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?

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Received: 2 August 2012; in revised form: 1 September 2012 / Accepted: 17 September 2012 / Published: 24 September 2012
(This article belongs to the Special Issue Immune Evasion)
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Abstract: The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this “novel” evasion strategy.
Keywords: neutralizing antibodies; non-neutralizing antibodies; interfering antibodies; viral escape mechanism neutralizing antibodies; non-neutralizing antibodies; interfering antibodies; viral escape mechanism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nicasio, M.; Sautto, G.; Clementi, N.; Diotti, R.A.; Criscuolo, E.; Castelli, M.; Solforosi, L.; Clementi, M.; Burioni, R. Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? Viruses 2012, 4, 1731-1752.

AMA Style

Nicasio M, Sautto G, Clementi N, Diotti RA, Criscuolo E, Castelli M, Solforosi L, Clementi M, Burioni R. Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? Viruses. 2012; 4(9):1731-1752.

Chicago/Turabian Style

Nicasio, Mancini; Sautto, Giuseppe; Clementi, Nicola; Diotti, Roberta A.; Criscuolo, Elena; Castelli, Matteo; Solforosi, Laura; Clementi, Massimo; Burioni, Roberto. 2012. "Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?" Viruses 4, no. 9: 1731-1752.



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