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Viruses 2012, 4(8), 1305-1317; doi:10.3390/v4081305
Review
A Review of Filovirus Work and Facilities at The Defence Science and Technology Laboratory Porton Down
Biomedical Sciences Department, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
* Author to whom correspondence should be addressed.
Received: 26 July 2012; in revised form: 14 August 2012 / Accepted: 15 August 2012 / Published: 17 August 2012
(This article belongs to the Special Issue Advances in Filovirus Research 2012)
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Abstract: Porton Down houses two separate sites capable of conducting high containment research on ACDP (Advisory Committee on Dangerous Pathogens) Hazard Group 4 agents: the Defence Science and Technology Laboratory (Dstl) and the Health Protection Agency (HPA), and filovirus research has been performed at Porton Down since the first Marburg virus disease outbreak in 1967. All work is conducted within primary containment either within cabinet lines (for in vitro work) or large rigid half-suit isolators (for in vivo work). There are extensive aerobiological facilities at high containment and the use of these facilities will be reported. Research at Dstl is primarily focused on assessing and quantifying the hazard, and testing the efficacy of medical countermeasures against filoviruses. Fundamental research directed to the study and understanding of the infectious and pathogenic nature of the filoviruses, particularly in aerosols, will be reported.
Keywords: Porton Down; facilities; containment; filovirus; research; aerosol; models; marmoset
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MDPI and ACS Style
Smither, S.J.; Lever, M.S. A Review of Filovirus Work and Facilities at The Defence Science and Technology Laboratory Porton Down. Viruses 2012, 4, 1305-1317.
AMA StyleSmither SJ, Lever MS. A Review of Filovirus Work and Facilities at The Defence Science and Technology Laboratory Porton Down. Viruses. 2012; 4(8):1305-1317.
Chicago/Turabian StyleSmither, Sophie J.; Lever, Mark S. 2012. "A Review of Filovirus Work and Facilities at The Defence Science and Technology Laboratory Porton Down." Viruses 4, no. 8: 1305-1317.