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Viruses 2012, 4(8), 1289-1304; doi:10.3390/v4081289
Article

Whole Genomic Analysis of Human G1P[8] Rotavirus Strains From Different Age Groups in China

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Received: 23 July 2012; in revised form: 13 August 2012 / Accepted: 15 August 2012 / Published: 16 August 2012
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Abstract: G1P[8] rotaviruses are an important cause of diarrhea in humans in China. To date, there are no reports on the whole genomic analysis of the Chinese G1P[8] rotaviruses. To determine the origin and overall genetic makeup of the recent Chinese G1P[8] strains, the whole genomes of three strains, RVA/Human-wt/CHN/E1911/2009/G1P[8], RVA/Human-tc/CHN/R588/2005/G1P[8] and RVA/Human-tc/CHN/Y128/2004/G1P[8], detected in an infant, a child and an adult, respectively, were analyzed. Strains E1911, R588 and Y128 exhibited a typical Wa-like genotype constellation. Except for the NSP3 gene of E1911, the whole genomes of strains E1911, R588 and Y128 were found to be more closely related to those of the recent Wa-like common human strains from different countries than those of the prototype G1P[8] strain, or other old strains. On the other hand, the NSP3 gene of E1911 was genetically distinct from those of Y128, R588, or other Wa-like common human strains, and appeared to share a common origin with those of the porcine-like human G9 strains, providing evidence for intergenotype reassortment events. Comparisons of the amino acid residues defining the VP7 and VP4 antigenic domains revealed several mismatches between these Chinese G1P[8] strains and the G1 and P[8] strains contained in the currently licensed rotavirus vaccines RotarixTM and RotaTeqTM.
Keywords: human G1P[8] rotavirus; whole genomic analysis; China human G1P[8] rotavirus; whole genomic analysis; China
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shintani, T.; Ghosh, S.; Wang, Y.-H.; Zhou, X.; Zhou, D.-J.; Kobayashi, N. Whole Genomic Analysis of Human G1P[8] Rotavirus Strains From Different Age Groups in China. Viruses 2012, 4, 1289-1304.

AMA Style

Shintani T, Ghosh S, Wang Y-H, Zhou X, Zhou D-J, Kobayashi N. Whole Genomic Analysis of Human G1P[8] Rotavirus Strains From Different Age Groups in China. Viruses. 2012; 4(8):1289-1304.

Chicago/Turabian Style

Shintani, Tsuzumi; Ghosh, Souvik; Wang, Yuan-Hong; Zhou, Xuan; Zhou, Dun-Jin; Kobayashi, Nobumichi. 2012. "Whole Genomic Analysis of Human G1P[8] Rotavirus Strains From Different Age Groups in China." Viruses 4, no. 8: 1289-1304.


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