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Whole Genomic Analysis of Human G1P Rotavirus Strains From Different Age Groups in China
AbstractG1P rotaviruses are an important cause of diarrhea in humans in China. To date, there are no reports on the whole genomic analysis of the Chinese G1P rotaviruses. To determine the origin and overall genetic makeup of the recent Chinese G1P strains, the whole genomes of three strains, RVA/Human-wt/CHN/E1911/2009/G1P, RVA/Human-tc/CHN/R588/2005/G1P and RVA/Human-tc/CHN/Y128/2004/G1P, detected in an infant, a child and an adult, respectively, were analyzed. Strains E1911, R588 and Y128 exhibited a typical Wa-like genotype constellation. Except for the NSP3 gene of E1911, the whole genomes of strains E1911, R588 and Y128 were found to be more closely related to those of the recent Wa-like common human strains from different countries than those of the prototype G1P strain, or other old strains. On the other hand, the NSP3 gene of E1911 was genetically distinct from those of Y128, R588, or other Wa-like common human strains, and appeared to share a common origin with those of the porcine-like human G9 strains, providing evidence for intergenotype reassortment events. Comparisons of the amino acid residues defining the VP7 and VP4 antigenic domains revealed several mismatches between these Chinese G1P strains and the G1 and P strains contained in the currently licensed rotavirus vaccines RotarixTM and RotaTeqTM.
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Shintani, T.; Ghosh, S.; Wang, Y.-H.; Zhou, X.; Zhou, D.-J.; Kobayashi, N. Whole Genomic Analysis of Human G1P Rotavirus Strains From Different Age Groups in China. Viruses 2012, 4, 1289-1304.View more citation formats
Shintani T, Ghosh S, Wang Y-H, Zhou X, Zhou D-J, Kobayashi N. Whole Genomic Analysis of Human G1P Rotavirus Strains From Different Age Groups in China. Viruses. 2012; 4(8):1289-1304.Chicago/Turabian Style
Shintani, Tsuzumi; Ghosh, Souvik; Wang, Yuan-Hong; Zhou, Xuan; Zhou, Dun-Jin; Kobayashi, Nobumichi. 2012. "Whole Genomic Analysis of Human G1P Rotavirus Strains From Different Age Groups in China." Viruses 4, no. 8: 1289-1304.