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Viruses 2011, 3(3), 254-259; doi:10.3390/v3030254
Commentary

A New Role for the HTLV-1 p8 Protein: Increasing Intercellular Conduits and Viral Cell-to-Cell Transmission

,  and *
Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 15 February 2011 / Revised: 2 March 2011 / Accepted: 2 March 2011 / Published: 9 March 2011
(This article belongs to the Section Editorial)
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Abstract

Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8.
Keywords: HTLV-1; HIV-1; cell-to-cell transfer; virological synapses; cellular conduits; p8; p12; Nef HTLV-1; HIV-1; cell-to-cell transfer; virological synapses; cellular conduits; p8; p12; Nef
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Malbec, M.; Roesch, F.; Schwartz, O. A New Role for the HTLV-1 p8 Protein: Increasing Intercellular Conduits and Viral Cell-to-Cell Transmission. Viruses 2011, 3, 254-259.

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