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Viruses 2010, 2(8), 1564-1570; doi:10.3390/v2081564
Short Note

Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report

1
,
2
,
3
,
4
,
4
,
5
 and
5,6,*
1 Infektionsmedizinisches Centrum Hamburg (ICH St. Georg), Germany 2 IPM Biotech GmbH, Labor Lademannbogen, Hamburg, Germany 3 Heinrich-Pette-Institute, Hamburg, Germany 4 University Hospital Eppendorf (UKE), Hamburg, Germany 5 University Hospital Bonn, Germany 6 Kliniken der Stadt Köln gGmbH, Cologne, Germany
* Author to whom correspondence should be addressed.
Received: 24 June 2010 / Revised: 16 July 2010 / Accepted: 28 July 2010 / Published: 29 July 2010
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Abstract

A first case of clinical tenofovir (TDF) HBV resistance in an HIV/HBV coinfected patient who developed an acute flare of hepatitis B is reported. The clinical course was accompanied by signs of acute liver failure after being on successful HBV treatment with tenofovir and persistently undetectable HBV-DNA viral load for over five years.
Keywords: HIV-HBV-coinfection; tenofovir; clinical HBV resistance HIV-HBV-coinfection; tenofovir; clinical HBV resistance
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Schewe, K.; Noah, C.; Sirma, H.; Schmiedel, S.; van Lunzen, J.; Rockstroh, J.K.; Schildgen, O. Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report. Viruses 2010, 2, 1564-1570.

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