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Viruses 2010, 2(8), 1564-1570; doi:10.3390/v2081564
Short Note
Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report
Knud Schewe 1 
, Christian Noah 2 , Hüseyin Sirma 3 , Stefan Schmiedel 4 , Jan van Lunzen 4 , Jürgen Kurt Rockstroh 5 and Oliver Schildgen 5,6,*
, Christian Noah 2 , Hüseyin Sirma 3 , Stefan Schmiedel 4 , Jan van Lunzen 4 , Jürgen Kurt Rockstroh 5 and Oliver Schildgen 5,6,*
1
Infektionsmedizinisches Centrum Hamburg (ICH St. Georg), Germany
2
IPM Biotech GmbH, Labor Lademannbogen, Hamburg, Germany
3
Heinrich-Pette-Institute, Hamburg, Germany
4
University Hospital Eppendorf (UKE), Hamburg, Germany
5
University Hospital Bonn, Germany
6
Kliniken der Stadt Köln gGmbH, Cologne, Germany
* Author to whom correspondence should be addressed.
Received: 24 June 2010; in revised form: 16 July 2010 / Accepted: 28 July 2010 / Published: 29 July 2010
Download PDF Full-Text [80 KB, uploaded 29 July 2010 14:34 CEST]
Abstract: A first case of clinical tenofovir (TDF) HBV resistance in an HIV/HBV coinfected patient who developed an acute flare of hepatitis B is reported. The clinical course was accompanied by signs of acute liver failure after being on successful HBV treatment with tenofovir and persistently undetectable HBV-DNA viral load for over five years.
Keywords: HIV-HBV-coinfection; tenofovir; clinical HBV resistance
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MDPI and ACS Style
Schewe, K.; Noah, C.; Sirma, H.; Schmiedel, S.; van Lunzen, J.; Rockstroh, J.K.; Schildgen, O. Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report. Viruses 2010, 2, 1564-1570.
AMA StyleSchewe K, Noah C, Sirma H, Schmiedel S, van Lunzen J, Rockstroh JK, Schildgen O. Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report. Viruses. 2010; 2(8):1564-1570.
Chicago/Turabian StyleSchewe, Knud; Noah, Christian; Sirma, Hüseyin; Schmiedel, Stefan; van Lunzen, Jan; Rockstroh, Jürgen Kurt; Schildgen, Oliver. 2010. "Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report." Viruses 2, no. 8: 1564-1570.