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Viruses 2010, 2(4), 867-879; doi:10.3390/v2040867
Article

The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

1
,
2
,
1
,
1,*  and 3
1 Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden 2 Gay Men’s Health Clinic, Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, SE-118 83 Stockholm, Sweden 3 Department of Infectious Diseases, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden
* Author to whom correspondence should be addressed.
Received: 2 December 2009 / Revised: 24 February 2010 / Accepted: 2 March 2010 / Published: 29 March 2010
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Abstract

We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.
Keywords: Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Friis, A.M.C.; Gyllensten, K.; Aleman, A.; Ernberg, I.; Åkerlund, B. The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients. Viruses 2010, 2, 867-879.

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