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Viruses 2010, 2(4), 867-879; doi:10.3390/v2040867
Article

The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

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Received: 2 December 2009 / Revised: 24 February 2010 / Accepted: 2 March 2010 / Published: 29 March 2010
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Abstract

We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.
Keywords: Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Friis, A.M.C.; Gyllensten, K.; Aleman, A.; Ernberg, I.; Åkerlund, B. The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients. Viruses 2010, 2, 867-879.

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