Next Article in Journal
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate
Previous Article in Journal
Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care
Article Menu

Export Article

Open AccessArticle
Viruses 2010, 2(4), 867-879; doi:10.3390/v2040867

The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

1
Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden
2
Gay Men’s Health Clinic, Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, SE-118 83 Stockholm, Sweden
3
Department of Infectious Diseases, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Received: 2 December 2009 / Revised: 24 February 2010 / Accepted: 2 March 2010 / Published: 29 March 2010
View Full-Text   |   Download PDF [175 KB, uploaded 12 May 2015]   |  

Abstract

We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.
Keywords: Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Friis, A.M.C.; Gyllensten, K.; Aleman, A.; Ernberg, I.; Åkerlund, B. The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients. Viruses 2010, 2, 867-879.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top