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Viruses 2010, 2(2), 655-675; doi:10.3390/v2020655
Article

Restriction of Rift Valley Fever Virus Virulence in Mosquito Cells

†,1
, †,2
, 3,4
 and 2,*
1 Medical Scientist Training Program, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA 2 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA 3 Department of Microbiology and Immunology, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA 4 Internal Medicine School of Medicine, University of Michigan, Ann Arbor, Michigan, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 15 December 2009 / Revised: 7 February 2010 / Accepted: 10 February 2010 / Published: 17 February 2010
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Abstract

Arboviruses are maintained in a natural cycle that requires blood-sucking arthropod and vertebrate hosts. Arboviruses are believed to persistently infect their arthropod host without overt pathology and cause acute infection with viremia in their vertebrate host. We have focused on elucidating how a specific arbovirus, Rift Valley fever (RVF) virus, causes cytopathic effect in cells derived from vertebrates and non-cytopathic infection in cells derived from arthropods. We demonstrate that the vertebrate virulence factor, NSs, is functional in arthropod cells but is expressed at significantly lower levels in infected arthropod versus infected vertebrate cells.
Keywords: arbovirus; arthropod; NSs; non-structural protein; innate immunity; cytopathic effect; virulence factor arbovirus; arthropod; NSs; non-structural protein; innate immunity; cytopathic effect; virulence factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vaughn, V.M.; Streeter, C.C.; Miller, D.J.; Gerrard, S.R. Restriction of Rift Valley Fever Virus Virulence in Mosquito Cells. Viruses 2010, 2, 655-675.

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