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Viruses 2018, 10(9), 484; https://doi.org/10.3390/v10090484

Susceptibility Genes to Plant Viruses

Nebraska Center for Virology, Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE 68503, USA
Received: 5 July 2018 / Revised: 28 August 2018 / Accepted: 7 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Plant-Virus Interactions)
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Abstract

Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors that condition susceptibility to plant viruses. Host factors with proviral activity have been identified for all parts of the virus infection cycle: viral RNA translation, viral replication complex formation, accumulation or activity of virus replication proteins, virus movement, and virion assembly. These factors could be targets of gene editing to engineer resistance to plant viruses. View Full-Text
Keywords: virus susceptibility genes; antiviral defense; virus movement; gene silencing; virus resistance; virus accumulation; host factors virus susceptibility genes; antiviral defense; virus movement; gene silencing; virus resistance; virus accumulation; host factors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Garcia-Ruiz, H. Susceptibility Genes to Plant Viruses. Viruses 2018, 10, 484.

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