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Viruses 2018, 10(7), 367; https://doi.org/10.3390/v10070367

The C-Type Lectin Domain Gene Family in Aedes aegypti and Their Role in Arbovirus Infection

Department of Entomology and Agrilife Research, Texas A&M University, College Station, TX 77843, USA
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Received: 15 June 2018 / Revised: 9 July 2018 / Accepted: 11 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Antiviral Defense in Invertebrates)
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Abstract

Several medically important flaviviruses that are transmitted by mosquitoes have been shown to bind to the C-type lectin fold that is present in either vertebrate or invertebrate proteins. While in some cases this interaction is part of a neutralizing anti-viral immune response, many reports have implicated this as critical for successful virus entry. Despite the establishment of mosquito C-type lectin domain containing proteins (CTLDcps) as known host factors in assisting the infectious process for flaviviruses, little is known about the structural characteristics of these proteins and their relationships to each other. In this report, we describe the manual annotation and structural characterization of 52 Aedes aegypti CTLDcps. Using existing RNAseq data, we establish that these genes can be subdivided into two classes: those highly conserved with expression primarily in development (embryo/early larvae) and those with no clear orthologs with expression primarily in late larvae/pupae or adults. The latter group contained all CTLDcps that are regulated by the Toll/Imd immune pathways, all known microbiome-regulating CTLDcps, and almost all CTLDcps that are implicated as flavivirus host factors in A. aegypti. Finally, we attempt to synthesize results from multiple conflicting gene expression profiling experiments in terms of how flavivirus infection changes steady-state levels of mRNA encoding CTLDcps. View Full-Text
Keywords: Aedes aegypti; arbovirus; C-type lectin; dengue; mosquito; immunity; host factor Aedes aegypti; arbovirus; C-type lectin; dengue; mosquito; immunity; host factor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Adelman, Z.N.; Myles, K.M. The C-Type Lectin Domain Gene Family in Aedes aegypti and Their Role in Arbovirus Infection. Viruses 2018, 10, 367.

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