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Viruses 2018, 10(5), 267; https://doi.org/10.3390/v10050267

Drug Delivery Strategies for Antivirals against Hepatitis B Virus

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
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Received: 21 April 2018 / Revised: 4 May 2018 / Accepted: 8 May 2018 / Published: 17 May 2018
(This article belongs to the Section Antivirals & Vaccines)
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Abstract

Chronic hepatitis B virus (HBV) infection poses a significant health challenge due to associated morbidity and mortality from cirrhosis and hepatocellular cancer that eventually results in the breakdown of liver functionality. Nanotechnology has the potential to play a pivotal role in reducing viral load levels and drug-resistant HBV through drug targeting, thus reducing the rate of evolution of the disease. Apart from tissue targeting, intracellular delivery of a wide range of drugs is necessary to exert a therapeutic action in the affected organelles. This review encompasses the strategies and techniques that have been utilized to target the HBV-infected nuclei in liver hepatocytes, with a significant look at the new insights and most recent advances in drug carriers and their role in anti-HBV therapy. View Full-Text
Keywords: Hepatitis B virus; intracellular drug delivery; liver targeting; hepatocyte; asialoglycoprotein receptor; nanoparticles; cell-penetrating peptides Hepatitis B virus; intracellular drug delivery; liver targeting; hepatocyte; asialoglycoprotein receptor; nanoparticles; cell-penetrating peptides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Singh, L.; Indermun, S.; Govender, M.; Kumar, P.; du Toit, L.C.; Choonara, Y.E.; Pillay, V. Drug Delivery Strategies for Antivirals against Hepatitis B Virus. Viruses 2018, 10, 267.

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