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Viruses 2018, 10(5), 255; https://doi.org/10.3390/v10050255

A Review of the Ongoing Research on Zika Virus Treatment

1
Laboratory of Virology, Institute of Biomedical Science, ICBIM, Federal University of Uberlândia, Uberlândia, MG 38405-302, Brazil
2
Genomics Study Laboratory, São Paulo State University, IBILCE, São José do Rio Preto, SP 15054-000, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 February 2018 / Revised: 11 April 2018 / Accepted: 14 April 2018 / Published: 14 May 2018
(This article belongs to the Section Antivirals & Vaccines)
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Abstract

The Zika fever is an arboviral disease resulting from the infection with Zika virus (ZIKV). The virus is transmitted to humans by the bite of Aedes mosquitos, mainly Aedes aegypti and Aedes albopictus. ZIKV has been detected for decades in African and Asian regions and, since 2007, has spread to other continents; among them, infections are most reported in the Americas. This can be explained by the presence of vectors in highly populated and tropical regions where people are susceptible to contamination. ZIKV has been considered by the World Health Organization a serious public health problem because of the increasing number of cases of congenital malformation and neurological disorders related to its infection, such as microcephaly, Guillain–Barré syndrome, meningoencephalitis, and myelitis. There is no vaccine or specific antiviral against ZIKV. The infection is best prevented by avoiding mosquito bite, and the treatment of infected patients is palliative. In this context, the search for efficient antivirals is necessary but remains challenging. Here, we aim to review the molecules that have been described to interfere with ZIKV life cycle and discuss their potential use in ZIKV therapy. View Full-Text
Keywords: Zika fever; ZIKV; treatment; antiviral; screen of drugs Zika fever; ZIKV; treatment; antiviral; screen of drugs
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da Silva, S.; Oliveira Silva Martins, D.; Jardim, A.C.G. A Review of the Ongoing Research on Zika Virus Treatment. Viruses 2018, 10, 255.

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