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Viruses 2018, 10(4), 203; https://doi.org/10.3390/v10040203

Remembering Jan Svoboda: A Personal Reflection

Division of Infection & Immunity, University College London, London WC1E 6BT, UK
Received: 28 March 2018 / Revised: 15 April 2018 / Accepted: 16 April 2018 / Published: 18 April 2018
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Abstract

The Czech scientist Jan Svoboda was a pioneer of Rous sarcoma virus (RSV). In the 1960s, before the discovery of reverse transcriptase, he demonstrated the long-term persistence of the viral genome in non-productive mammalian cells, and he supported the DNA provirus hypothesis of Howard Temin. He showed how the virus can be rescued in the infectious form and elucidated the replication-competent nature of the Prague strain of RSV later used for the identification of the src oncogene. His studies straddled molecular oncology and virology, and he remained an active contributor to the field until his death last year. Throughout the 50 years that I was privileged to know Svoboda as my mentor and friend, I admired his depth of scientific inquiry and his steadfast integrity in the face of political oppression. View Full-Text
Keywords: Rous sarcoma virus; persistent infection; cell transformation; Prague Spring Rous sarcoma virus; persistent infection; cell transformation; Prague Spring
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Weiss, R.A. Remembering Jan Svoboda: A Personal Reflection. Viruses 2018, 10, 203.

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