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Viruses 2009, 1(3), 818-831; doi:10.3390/v1030818
Review
Hepatitis Delta Virus RNA Replication
Chung-Hsin Tseng 1 and Michael M. C. Lai 1,2,3,* 
1
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
2
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
3
National Cheng-Kung University, Tainan 701, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 September 2009; in revised form: 3 November 2009 / Accepted: 3 November 2009 / Published: 6 November 2009
(This article belongs to the Special Issue Subviral RNAs)
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Abstract: Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen (HDAg), which is indispensible for HDV replication, is a unique feature distinct from plant viroids, which do not encode any protein. Here the HDV RNA replication cycle is reviewed, with emphasis on the function of HDAg in modulating RNA replication and the nature of the enzyme involved.
Keywords: hepatitis delta virus; hepatitis delta antigen; RNA-dependent RNA synthesis; RNA polymerases; RNA replication
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MDPI and ACS Style
Tseng, C.-H.; Lai, M.M.C. Hepatitis Delta Virus RNA Replication. Viruses 2009, 1, 818-831.
AMA StyleTseng C.-H., Lai M.M.C. Hepatitis Delta Virus RNA Replication. Viruses. 2009; 1(3):818-831.
Chicago/Turabian StyleTseng, Chung-Hsin; Lai, Michael M. C. 2009. "Hepatitis Delta Virus RNA Replication." Viruses 1, no. 3: 818-831.
Viruses
EISSN 1999-4915
Published by MDPI Publishing, Basel, Switzerland
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