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Viruses 2009, 1(3), 594-629; doi:10.3390/v1030594
Review
Herpes Virus Amplicon Vectors
Suresh de Silva 1,2,3 
and William J. Bowers 2,3,4,5,*
and William J. Bowers 2,3,4,5,*
1
Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
2 Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
3 School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
4 Department of Neurology, University of Rochester, Rochester, NY 14642, USA
5 Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
2 Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
3 School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
4 Department of Neurology, University of Rochester, Rochester, NY 14642, USA
5 Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
* Author to whom correspondence should be addressed.
Received: 30 September 2009; in revised form: 26 October 2009 / Accepted: 29 October 2009 / Published: 29 October 2009
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
Download PDF Full-Text [369 KB, uploaded 29 October 2009 17:01 CET]
Abstract: Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing.
Keywords: herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration
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MDPI and ACS Style
de Silva, S.; Bowers, W.J. Herpes Virus Amplicon Vectors. Viruses 2009, 1, 594-629.
AMA Stylede Silva S., Bowers W.J. Herpes Virus Amplicon Vectors. Viruses. 2009; 1(3):594-629.
Chicago/Turabian Stylede Silva, Suresh; Bowers, William J. 2009. "Herpes Virus Amplicon Vectors." Viruses 1, no. 3: 594-629.
Viruses
EISSN 1999-4915
Published by MDPI Publishing, Basel, Switzerland
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