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Algorithms 2009, 2(3), 1155-1176; doi:10.3390/a2031155
Review

Algorithm for the Analysis of Tryptophan Fluorescence Spectra and Their Correlation with Protein Structural Parameters

 and
*
Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI 02881, USA
* Author to whom correspondence should be addressed.
Received: 15 July 2009 / Revised: 20 August 2009 / Accepted: 10 September 2009 / Published: 16 September 2009
(This article belongs to the Special Issue Algorithms and Molecular Sciences)
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Abstract

The fluorescence properties of tryptophan residues are sensitive to the microenvironment of fluorophores in proteins. Therefore, fluorescence characteristics are widely used to study structural transitions in proteins. However, the decoding of the structural information from spectroscopic data is challenging. Here we present a review of approaches developed for the decomposition of multi-component protein tryptophan fluorescence spectra and correlation of these spectral parameters with protein structural properties.
Keywords: protein fluorescence; protein structure; decomposition; structural analysis; tryptophan; statistical methods protein fluorescence; protein structure; decomposition; structural analysis; tryptophan; statistical methods
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hixon, J.; Reshetnyak, Y.K. Algorithm for the Analysis of Tryptophan Fluorescence Spectra and Their Correlation with Protein Structural Parameters. Algorithms 2009, 2, 1155-1176.

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