Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Cavity Disinfectants Preparation
4.2. Microtensile Bond Testing
4.3. Dentin Beams Proteolytic Degradation Assay
4.4. Inhibition Effects on Bacteria Relating to Dentin Caries Impregnated in Dentin
4.5. Statistical Analyses
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
- David, H.P.; Franklin, R.T.; Lorenzo, B.; Leo, T.; Ricardo, M.C.; Marcela, C.; Arzu, T.M. State of the art etch-and-rinse adhesives. Dent. Mater. 2011, 27, 1–16. [Google Scholar]
- Manhart, J.; Chen, H.; Hamm, G.; Hickel, R. Buonocore Memorial Lecture. Review of the clinical survival of direct and indirect restorations in posterior teeth of the permanent dentition. Oper. Dent. 2004, 29, 481–508. [Google Scholar] [PubMed]
- Meiers, J.C.; Shook, L.W. Effect of disinfectants on the bond strength of composite to dentin. Am. J. Dent. 1996, 9, 11–14. [Google Scholar] [PubMed]
- Cheng, L.; Zhang, K.; Weir, M.D.; Liu, H.; Zhou, X.; Xu, H.H. Effects of antibacterial primers with quaternary ammonium and nano-silver on Streptococcus mutans impregnated in human dentin blocks. Dent. Mater. 2013, 29, 462–472. [Google Scholar] [CrossRef] [PubMed]
- Peumans, M.; Kanumilli, P.; De Munck, J.; Van Landuyt, K.; Lambrechts, P.; Van Meerbeek, B. Clinical effectiveness of contemporary adhesives: A systematic review of current clinical trials. Dent. Mater. 2005, 21, 864–881. [Google Scholar] [CrossRef] [PubMed]
- Kimyai, S.; Mehdipour, M.; Savadi Oskoee, S.; Alizadeh Oskoee, P.; Abbaszadeh, A. Reasons for Retreatment of Amalgam and Composite Restorations among the Patients Referring to Tabriz Faculty of Dentistry. J. Dent. Res. Dent. Clin. Dent. Prospects 2007, 1, 27–31. [Google Scholar] [PubMed]
- Zhang, N.; Weir, M.D.; Romberg, E.; Bai, Y.; Xu, H.H. Development of novel dental adhesive with double benefits of protein-repellent and antibacterial capabilities. Dent. Mater. 2015, 31, 845–854. [Google Scholar] [CrossRef] [PubMed]
- Bergenholtz, G. Evidence for bacterial causation of adverse pulpal responses in resin-based dental restorations. Crit. Rev. Oral. Biol. Med. 2000, 11, 467–480. [Google Scholar] [CrossRef] [PubMed]
- Tjaderhane, L.; Nascimento, F.D.; Breschi, L.; Mazzoni, A.; Tersariol, I.L.; Geraldeli, S.; Tezvergil-Mutluay, A.; Carrilho, M.R.; Carvalho, R.M.; Tay, F.R.; et al. Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. Dent. Mater. 2013, 29, 116–135. [Google Scholar] [CrossRef] [PubMed]
- Hiraishi, N.; Yiu, C.K.; King, N.M.; Tay, F.R. Effect of 2% chlorhexidine on dentin microtensile bond strengths and nanoleakage of luting cements. J. Dent. 2009, 37, 440–448. [Google Scholar] [CrossRef] [PubMed]
- Breschi, L.; Mazzoni, A.; Ruggeri, A.; Cadenaro, M.; Di Lenarda, R.; De Stefano Dorigo, E. Dental adhesion review: Aging and stability of the bonded interface. Dent. Mater. 2008, 24, 90–101. [Google Scholar] [CrossRef] [PubMed]
- Fang, M.; Liu, R.; Xiao, Y.; Li, F.; Wang, D.; Hou, R.; Chen, J. Biomodification to dentin by a natural crosslinker improved the resin-dentin bonds. J. Dent. 2012, 40, 458–466. [Google Scholar] [CrossRef] [PubMed]
- Osorio, R.; Yamauti, M.; Osorio, E.; Ruiz-Requena, M.E.; Pashley, D.; Tay, F.; Toledano, M. Effect of dentin etching and chlorhexidine application on metalloproteinase-mediated collagen degradation. Eur. J. Oral. Sci. 2011, 119, 79–85. [Google Scholar] [CrossRef] [PubMed]
- Green, B.; Yao, X.; Ganguly, A.; Xu, C.; Dusevich, V.; Walker, M.P.; Wang, Y. Grape seed proanthocyanidins increase collagen biodegradation resistance in the dentin/adhesive interface when included in an adhesive. J. Dent. 2010, 38, 908–915. [Google Scholar] [CrossRef] [PubMed]
- Pashley, D.H.; Tay, F.R.; Imazato, S. How to increase the durability of resin-dentin bonds. Compend Contin. Educ. Dent. 2011, 32, 60–64. [Google Scholar] [PubMed]
- Carvalho, R.M.; Manso, A.P.; Geraldeli, S.; Tay, F.R.; Pashley, D.H. Durability of bonds and clinical success of adhesive restorations. Dent. Mater. 2012, 28, 72–86. [Google Scholar] [CrossRef] [PubMed]
- Liu, Y.; Tjaderhane, L.; Breschi, L.; Mazzoni, A.; Li, N.; Mao, J.; Pashley, D.H.; Tay, F.R. Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J. Dent. Res. 2011, 90, 953–968. [Google Scholar] [CrossRef] [PubMed]
- Hiraishi, N.; Yiu, C.K.; King, N.M.; King, N.M.; Tay, F.R.; Pashley, D.H. Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins. Dent. Mater. 2008, 24, 1391–1399. [Google Scholar] [CrossRef] [PubMed]
- Li, F.; Weir, M.D.; Xu, H.H. Effects of quaternary ammonium chain length on antibacterial bonding agents. J. Dent. Res. 2013, 92, 932–938. [Google Scholar] [CrossRef] [PubMed]
- Cheng, L.; Zhang, K.; Melo, M.A.; Weir, M.D.; Zhou, X.; Xu, H.H. Anti-biofilm dentin primer with quaternary ammonium and silver nanoparticles. J. Dent. Res. 2012, 91, 598–604. [Google Scholar] [CrossRef] [PubMed]
- Zhang, K.; Cheng, L.; Wu, E.J.; Weir, M.D.; Bai, Y.; Xu, H.H.K. Effect of water-ageing on dentine bond strength and anti-biofilm activity of bonding agent containing new monomer dimethylaminododecyl methacrylate. J. Dent. 2013, 41, 504–513. [Google Scholar] [CrossRef] [PubMed]
- Melo, M.A.; Wu, J.; Weir, M.D.; Xu, H.H. Novel antibacterial orthodontic cement containing quaternary ammonium monomer dimethylaminododecyl methacrylate. J. Dent. 2014, 42, 1193–1201. [Google Scholar] [CrossRef] [PubMed]
- Zhang, K.; Melo, M.A.; Cheng, L.; Weir, M.D.; Bai, Y.; Xu, H.H. Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms. Dent. Mater. 2012, 28, 842–852. [Google Scholar] [CrossRef] [PubMed]
- Imazato, S.; Chen, J.H.; Ma, S.; Izutani, N.; Li, F. Antibacterial resin monomers based on quaternary ammonium and their benefits in restorative dentistry. Jpn. Dent. Sci. Rev. 2012, 48, 115–125. [Google Scholar] [CrossRef]
- Cheng, L.; Weir, M.D.; Xu, H.H.; Antonucci, J.M.; Kraigsley, A.M.; Lin, N.J.; Lin-Gibson, S.; Zhou, X. Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles. Dent. Mater. 2012, 28, 561–572. [Google Scholar] [CrossRef] [PubMed]
- Wang, S.-P.; Ge, Y.; Zhou, X.-D.; Xu, H.H.K.; Weir, M.D.; Zhang, K.-K.; Wang, H.-H.; Hannig, M.; Rupf, S.; Li, Q.; et al. Effect of anti-biofilm glass–ionomer cement on Streptococcus mutans biofilms. Int. J. Oral Sci. 2016, 29, 1–8. [Google Scholar] [CrossRef] [PubMed]
- Gurgan, S.; Bolay, S.; Kiremitci, A. Effect of disinfectant application methods on the bond strength of composite to dentin. J. Oral Rehabil. 1999, 26, 836–840. [Google Scholar] [CrossRef] [PubMed]
- Fardal, O.; Turnbull, R.S. A review of the literature on use of chlorhexidine in dentistry. J. Am. Dent. Assoc. 1986, 112, 863–869. [Google Scholar] [CrossRef] [PubMed]
- Tezvergil-Mutluay, A.; Agee, K.A.; Mazzoni, A.; Carvalho, R.M.; Carrilho, M.; Tersariol, I.L.; Nascimento, F.D.; Imazato, S.; Tjaderhane, L.; Breschi, L.; et al. Can quaternary ammonium methacrylates inhibit matrix MMPs and cathepsins? Dent. Mater. 2015, 31, e25–e32. [Google Scholar] [CrossRef] [PubMed]
- Mazzoni, A.; Scaffa, P.; Carrilho, M.; Tjaderhane, L.; Di Lenarda, R.; Polimeni, A.; Tezvergil-Mutluay, A.; Tay, F.R.; Pashley, D.H.; Breschi, L. Effects of etch-and-rinse and self-etch adhesives on dentin MMP-2 and MMP-9. J. Dent. Res. 2013, 92, 82–86. [Google Scholar] [CrossRef] [PubMed]
- Chaussain-Miller, C.; Fioretti, F.; Goldberg, M.; Menashi, S. The role of matrix metalloproteinases (MMPs) in human caries. J. Dent. Res. 2006, 85, 22–32. [Google Scholar] [CrossRef] [PubMed]
- Tezvergil-Mutluay, A.; Agee, K.A.; Hoshika, T.; Uchiyama, T.; Tjaderhane, L.; Breschi, L.; Mazzoni, A.; Thompson, J.M.; McCracken, C.E.; Looney, S.W.; et al. Inhibition of MMPs by alcohols. Dent. Mater. 2011, 27, 926–933. [Google Scholar] [CrossRef] [PubMed]
- De Munck, J.; Van den Steen, P.E.; Mine, A.; Van Landuyt, K.L.; Poitevin, A.; Opdenakker, G.; Van Meerbeek, B. Inhibition of enzymatic degradation of adhesive-dentin interfaces. J. Dent. Res. 2009, 88, 1101–1106. [Google Scholar] [CrossRef] [PubMed]
- Kim, D.S.; Kim, J.; Choi, K.K.; Kim, S.Y. The influence of chlorhexidine on the remineralization of demineralized dentine. J. Dent. 2011, 39, 855–862. [Google Scholar] [CrossRef] [PubMed]
- Carrilho, M.R.; Carvalho, R.M.; Sousa, E.N.; Nicolau, J.; Breschi, L.; Mazzoni, A.; Tjaderhane, L.; Tay, F.R.; Agee, K.; Pashley, D.H. Substantivity of chlorhexidine to human dentin. Dent. Mater. 2010, 26, 779–785. [Google Scholar] [CrossRef] [PubMed]
- Stanislawczuk, R.; Pereira, F.; Munoz, M.A.; Luque, I.; Farago, P.V.; Reis, A.; Loguercio, A.D. Effects of chlorhexidine-containing adhesives on the durability of resin-dentine interfaces. J. Dent. 2014, 42, 39–47. [Google Scholar] [CrossRef] [PubMed]
- Stape, T.H.; Menezes Mde, S.; Barreto, B.D.C.; Naves, L.Z.; Aguiar, H.B.; Quagliatto, P.S.; Martins, L.R. Influence of chlorhexidine on dentin adhesive interface micromorphology and nanoleakage expression of resin cements. Microsc. Res. Tech. 2013, 76, 788–794. [Google Scholar] [CrossRef] [PubMed]
- Cheng, L.; Weir, M.D.; Zhang, K.; Arola, D.D.; Zhou, X.; Xu, H.H. Dental primer and adhesive containing a new antibacterial quaternary ammonium monomer dimethylaminododecyl methacrylate. J. Dent. 2013, 41, 345–355. [Google Scholar] [CrossRef] [PubMed]
- Loguercio, A.D.; Stanislawczuk, R.; Polli, L.G.; Costa, J.A.; Michel, M.D.; Reis, A. Influence of Chlorhexidine digluconate concentration and application time on resin-dentin bond strength durability. Eur. J. Oral. Sci. 2009, 117, 587–596. [Google Scholar] [CrossRef] [PubMed]
- Zhou, H.; Weir, M.D.; Antonucci, J.M.; Schumacher, G.E.; Zhou, X.D.; Xu, H.H. Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates. Int. J. Oral Sci. 2014, 6, 77–86. [Google Scholar] [CrossRef] [PubMed]
- Tezvergil-Mutluay, A.; Agee, K.A.; Uchiyama, T.; Imazato, S.; Mutluay, M.M.; Cadenaro, M.; Breschi, L.; Nishitani, Y.; Tay, F.R.; Pashley, D.H. The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs. J. Dent. Res. 2011, 90, 535–540. [Google Scholar] [CrossRef] [PubMed]
- Wang, S.; Zhang, K.; Zhou, X.; Xu, N.; Xu, H.H.; Weir, M.D.; Ge, Y.; Wang, S.; Li, M.; Li, Y.; et al. Antibacterial effect of dental adhesive containing dimethylaminododecyl methacrylate on the development of Streptococcus mutans biofilm. Int. J. Mol. Sci. 2014, 15, 12791–12806. [Google Scholar] [CrossRef] [PubMed]
- Zhang, K.; Wang, S.; Zhou, X.; Xu, H.H.; Weir, M.D.; Ge, Y.; Li, M.; Wang, S.; Li, Y.; Xu, X.; et al. Effect of antibacterial dental adhesive on multispecies biofilms formation. J. Dent. Res. 2015, 94, 622–629. [Google Scholar] [CrossRef] [PubMed]
- Hiraishi, N.; Sono, R.; Islam, M.S.; Otsuki, M.; Tagami, J.; Takatsuka, T. Effect of hesperidin in vitro on root dentine collagen and demineralization. J. Dent. 2011, 39, 391–396. [Google Scholar] [CrossRef] [PubMed]
- Tezvergil-Mutluay, A.; Mutluay, M.M.; Gu, L.-S.; Zhang, K.; Agee, K.A.; Carvalho, R.M.; Manso, A.; Carrilho, M.; Tay, F.R.; Breschi, L.; et al. The anti-MMP activity of benzalkonium chloride. J. Dent. 2011, 39, 57–64. [Google Scholar] [CrossRef] [PubMed]
- Shono, Y.; Terashita, M.; Shimada, J.; Kozono, Y.; Carvalho, R.M.; Russell, C.M.; Pashley, D.H. Durability of resin-dentin bonds. J. Adhes. Dent. 1999, 1, 211–218. [Google Scholar] [PubMed]
- Van Meerbeek, B.; De Munck, J.; Yoshida, Y.; Inoue, S.; Vargas, M.; Vijay, P.; Van Landuyt, K.; Lambrechts, P.; Vanherle, G. Buonocore memorial lecture. Adhesion to enamel and dentin: Current status and future challenges. Oper. Dent. 2003, 28, 215–235. [Google Scholar] [PubMed]
- Sudsangiam, S.; van Noort, R. Do dentin bond strength tests serve a useful purpose? J. Adhes. Dent. 1999, 1, 57–67. [Google Scholar] [PubMed]
- Khalil, A.A.; Abdelaziz, K.M. Bonding values of two contemporary ceramic inlay materials to dentin following simulated aging. J. Adv. Prosthodont. 2015, 7, 446. [Google Scholar] [CrossRef] [PubMed]
- Aguiar, T.R.; André, C.B.; Correr-Sobrinho, L.; Arrais, C.A.G.; Ambrosano, G.M.B.; Giannini, M. Effect of storage times and mechanical load cycling on dentin bond strength of conventional and self-adhesive resin luting cements. J. Prosthet. Dent. 2014, 111, 404–410. [Google Scholar] [CrossRef] [PubMed]
- Cheng, L.; Zhang, K.; Zhou, C.C.; Weir, M.D.; Zhou, X.D.; Xu, H.H. One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms. Int. J. Oral Sci. 2016, 3, 1–10. [Google Scholar] [CrossRef] [PubMed]
- Shafiei, F.; Memarpour, M. Effect of chlorhexidine application on long-term shear bond strength of resin cements to dentin. J. Prosthodont. Res. 2010, 54, 153–158. [Google Scholar] [CrossRef] [PubMed]
- Carrilho, M.R.; Carvalho, R.M.; de Goes, M.F.; di Hipólito, V.; Geraldeli, S.; Tay, F.R.; Pashley, D.H.; Tjäderhane, L. Chlorhexidine preserves dentin bond in vitro. J. Dent. Res. 2007, 86, 90–94. [Google Scholar] [CrossRef] [PubMed]
- Breschi, L.; Mazzoni, A.; Nato, F.; Carrilho, M.; Visintini, E.; Tjaderhane, L.; Ruggeri, A.J.; Tay, F.R.; Dorigo Ede, S.; Pashley, D.H. Chlorhexidine stabilizes the adhesive interface: A 2-year in vitro study. Dent. Mater. 2010, 26, 320–325. [Google Scholar] [CrossRef] [PubMed]
- McBain, A.J.; Sissons, C.; Ledder, R.G.; Sreenivasan, P.K.; De Vizio, W.; Gilbert, P. Development and characterization of a simple perfused oral microcosm. J. Appl. Microbiol. 2005, 98, 624–634. [Google Scholar] [CrossRef] [PubMed]
- Di Hipolito, V.; Rodrigues, F.P.; Piveta, F.B.; Azevedo Lda, C.; Bruschi Alonso, R.C.; Silikas, N.; Carvalho, R.M.; De Goes, M.F.; Perlatti D’Alpino, P.H. Effectiveness of self-adhesive luting cements in bonding to chlorhexidine-treated dentin. Dent. Mater. 2012, 28, 495–501. [Google Scholar] [CrossRef] [PubMed]
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Zhou, W.; Ren, B.; Zhou, X.; Xu, H.H.K.; Weir, M.D.; Li, M.; Feng, M.; Li, J.; Xu, X.; Cheng, L. Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate. Materials 2016, 9, 674. https://doi.org/10.3390/ma9080674
Zhou W, Ren B, Zhou X, Xu HHK, Weir MD, Li M, Feng M, Li J, Xu X, Cheng L. Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate. Materials. 2016; 9(8):674. https://doi.org/10.3390/ma9080674
Chicago/Turabian StyleZhou, Wen, Biao Ren, Xuedong Zhou, Hockin H.K. Xu, Michael D. Weir, Mingyun Li, Mingye Feng, Jiyao Li, Xin Xu, and Lei Cheng. 2016. "Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate" Materials 9, no. 8: 674. https://doi.org/10.3390/ma9080674