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Materials 2016, 9(8), 674; doi:10.3390/ma9080674

Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate

State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China
Biomaterials &Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
Authors to whom correspondence should be addressed.
Academic Editor: Carsten Werner
Received: 25 June 2016 / Revised: 31 July 2016 / Accepted: 1 August 2016 / Published: 9 August 2016
(This article belongs to the Section Biomaterials)
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This study was set to assess the possible benefits of novel cavity disinfectants with 5% dimethylaminododecyl methacrylate (DMADDM); and compare the effectiveness of saliva microbial-aging method with water-aging in measuring the changing of resin–dentin bond strength. Three cavity disinfectants were tested: 0.2% Chlorhexidine (CHX); 5% DMADDM; and 5% DMADDM + 0.2% CHX. Microtensile bond strength (μTBS) test was performed after microbial-aging with saliva microbial or water aging for one month. Hydroxyproline (HYP), the production of collagen degradation, was measured spectrophotometrically. Additionally, the antibacterial effects of each reagent were evaluated. The 5% DMADDM exerted the least percentage of resin–dentin bond strength loss after one month microbial-aging (p < 0.05). There were no statistically significant differences of bond strength decrease after one month water aging among the tested groups (p > 0.05). Microbial-aging method yield more drop of bond strength than water aging in all groups except 5% DMADDM (p < 0.05). Meanwhile, 5% DMADDM had the same matrix metalloproteinases (MMPs) inhibitory effects as the other two agents (p > 0.05), but much stronger antibacterial capability than 0.2% CHX (p < 0.05). This indicated that a cavity disinfectant with 5% DMADDM is promising for improving the stability of resin–dentin bonds in appearance of saliva biofilm; and the saliva microbial-aging method is more promising for studying the durability of resin–dentin bonds than water aging. View Full-Text
Keywords: dimethyl aminododecyl methacrylate; chlorhexidine digluconate; dentin bond durability; MMPs inhibition; antibacterial; saliva microbial-aging dimethyl aminododecyl methacrylate; chlorhexidine digluconate; dentin bond durability; MMPs inhibition; antibacterial; saliva microbial-aging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhou, W.; Ren, B.; Zhou, X.; Xu, H.H.; Weir, M.D.; Li, M.; Feng, M.; Li, J.; Xu, X.; Cheng, L. Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate. Materials 2016, 9, 674.

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