Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate
AbstractThis study was set to assess the possible benefits of novel cavity disinfectants with 5% dimethylaminododecyl methacrylate (DMADDM); and compare the effectiveness of saliva microbial-aging method with water-aging in measuring the changing of resin–dentin bond strength. Three cavity disinfectants were tested: 0.2% Chlorhexidine (CHX); 5% DMADDM; and 5% DMADDM + 0.2% CHX. Microtensile bond strength (μTBS) test was performed after microbial-aging with saliva microbial or water aging for one month. Hydroxyproline (HYP), the production of collagen degradation, was measured spectrophotometrically. Additionally, the antibacterial effects of each reagent were evaluated. The 5% DMADDM exerted the least percentage of resin–dentin bond strength loss after one month microbial-aging (p < 0.05). There were no statistically significant differences of bond strength decrease after one month water aging among the tested groups (p > 0.05). Microbial-aging method yield more drop of bond strength than water aging in all groups except 5% DMADDM (p < 0.05). Meanwhile, 5% DMADDM had the same matrix metalloproteinases (MMPs) inhibitory effects as the other two agents (p > 0.05), but much stronger antibacterial capability than 0.2% CHX (p < 0.05). This indicated that a cavity disinfectant with 5% DMADDM is promising for improving the stability of resin–dentin bonds in appearance of saliva biofilm; and the saliva microbial-aging method is more promising for studying the durability of resin–dentin bonds than water aging. View Full-Text
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Zhou, W.; Ren, B.; Zhou, X.; Xu, H.H.; Weir, M.D.; Li, M.; Feng, M.; Li, J.; Xu, X.; Cheng, L. Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate. Materials 2016, 9, 674.
Zhou W, Ren B, Zhou X, Xu HH, Weir MD, Li M, Feng M, Li J, Xu X, Cheng L. Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate. Materials. 2016; 9(8):674.Chicago/Turabian Style
Zhou, Wen; Ren, Biao; Zhou, Xuedong; Xu, Hockin H.; Weir, Michael D.; Li, Mingyun; Feng, Mingye; Li, Jiyao; Xu, Xin; Cheng, Lei. 2016. "Novel Cavity Disinfectants Containing Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate." Materials 9, no. 8: 674.
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